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Experimental Models of Pituitary Tumorigenesis

  • Chapter
Diagnosis and Management of Pituitary Tumors

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Abstract

Pituitary tumors can be induced by chemicals, irradiation, target organ ablation, and genetic manipulations. Despite the availability of these models, pituitary tumorigenesis is still obscure. Depending on the approach, different types of pituitary tumors can be induced, including hormone-secreting or “silent” ones. Conditions similar to those existing in patients with gigantism, amenorrhea, galactorrhea, infertility, Cushing’s disease, hypothyroidism, or hypogonadism are created, giving the opportunity not only to obtain a deeper insight into the process of tumorigenesis, but also to test therapeutic modalities. The mouse, especially since the introduction of transgenic technology, is now replacing the rat, which has been the preferred species for inducing different experimental conditions, including pituitary tumors. It is important to emphasize that pituitary tumors arising in rodents are not identical to human ones and that extrapolation of the experimental results to human beings has some limitations. These differences could be attributed not only to the distinct morphologic features of hormone-containing cells of the rodent and human pituitaries but also to differences in the pituitary regulatory mechanisms among species.

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Authors
  1. Lucia Stefaneanu PhD
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Editors and Affiliations

  1. Division of Neurosurgery, Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada

    Kamal Thapar MD, PhD

  2. Department of Pathology and Laboratory Medicine, St. Michael’s Hospital, Toronto, Ontario, Canada

    Kalman Kovacs MD, PhD

  3. Department of Pathology, Mayo Clinic, Rochester, MN, USA

    Bernd W. Scheithauer MD  & Ricardo V. Lloyd MD, PhD  & 

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© 2001 Springer Science+Business Media New York

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Stefaneanu, L. (2001). Experimental Models of Pituitary Tumorigenesis. In: Thapar, K., Kovacs, K., Scheithauer, B.W., Lloyd, R.V. (eds) Diagnosis and Management of Pituitary Tumors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-217-3_6

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  • DOI: https://doi.org/10.1007/978-1-59259-217-3_6

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9693-2

  • Online ISBN: 978-1-59259-217-3

  • eBook Packages: Springer Book Archive

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