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Pituitary Tumors in Children

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Diagnosis and Management of Pituitary Tumors

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Abstract

The vast majority of pituitary tumors in children are benign lesions. The challenge for the clinical team, usually the neurosurgeon, endocrinologist, and neuroradiologist, is to diagnose those tumors accurately that arise in the suprasellar and sellar region, and to direct the initial and long-term treatment of these patients (1–3).

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References

  1. Chong BW, Newton TH. Hypothalamic and pituitary pathology. Radiol Clin North Am 1993;31:1147–1153.

    PubMed  CAS  Google Scholar 

  2. Styne DM. The therapy for hypothalamic-pituitary tumors. Endocrinol Metab Clin North Am 1993;22:631–648.

    PubMed  CAS  Google Scholar 

  3. Rutka JT, Hoffman HJ, Drake JM, Humphreys RP. Suprasellar and sellar tumors in childhood and adolescence. Neurosurg Clin North Am 1992;3:803–820.

    CAS  Google Scholar 

  4. Asa SL, Kovacs K, Laszlo FA, Domokos, I, Ezrin, C. Human fetal adenohypophysis. Histologic and immunocytochemical analysis. Neuroendocrinology 1986;43:308–316.

    PubMed  CAS  Google Scholar 

  5. Fisher DA, Klein, AH. Thyroid development and disorders of thyroid function in the newborn. N Engl J Med 1981;304:702–712.

    PubMed  CAS  Google Scholar 

  6. Kaplan SL, Grumbach MM, Aubert ML. The ontogenesis of pituitary hormones and hypothalamic factors in the human fetus: maturation of central nervous system regulation of anterior pituitary function. Recent Prog Horm Res 1976;32:161–243.

    PubMed  CAS  Google Scholar 

  7. Thliveris JA, Currie RW. Observations on the hypothalamo-hypophyseal portal vasculature in the developing human fetus. Am J Anat 1980;157:441–444.

    PubMed  CAS  Google Scholar 

  8. Wolpert SM, Osborne M, Anderson M, Runge VM. The bright pituitary gland-a normal MR appearance in infancy. AJNR 1988;9:1–3.

    PubMed  CAS  Google Scholar 

  9. Tien RD, Kucharczyk J, Bessette J, Middleton, M. MR imaging ofthe pituitary gland in infants and children: changes in size, shape, and MR signal with growth and development. N Engl J Med 1992;158:1151–1154.

    CAS  Google Scholar 

  10. Elster AD, Sanders TG, Vines FS, Chen MY. Size and shape of the pituitary gland during pregnancy and post partum: measurement with MR imaging. Radiology 1991;181:531–535.

    PubMed  CAS  Google Scholar 

  11. Sharafuddin MJ, Luisiri A, Garibaldi LR, Fulk DL, Klein JB, Gillespie, KN, et al. MR imaging diagnosis of central precocious puberty: importance of changes in the shape and size of the pituitary gland. AJR 1994;162:1167–1173.

    PubMed  CAS  Google Scholar 

  12. Elster AD, Chen MYM, Williams DW III, Key LL. Pituitary gland: MR imaging of physiologic hypertrophy in adolescence. Radiology 1990;174:681–685.

    PubMed  CAS  Google Scholar 

  13. Pollack IF. Brain tumors in children. N Engl J Med 1994;331: 1500–1507.

    PubMed  CAS  Google Scholar 

  14. Dyer EH, Civit T, Visot A, Delalande O, Derome P. Transsphenoidal surgery for pituitary adenomas in children. Neurosurgery 1994; 34:207–212.

    PubMed  CAS  Google Scholar 

  15. Mindermann T, Wilson CB. Pediatric pituitary adenomas. Neurosurgery 1995;36:259–268.

    PubMed  CAS  Google Scholar 

  16. Partington MD, Davis DH, Laws ER Jr, Scheithauer BW. Pituitary adenomas in childhood and adolescence. J Neurosurg 1994;80: 209–216.

    PubMed  CAS  Google Scholar 

  17. Kane LA, Leinung MC, Scheithauer BW, Bergstralh EJ, Laws ER Jr, Groover RV, et al. Pituitary adenomas in childhood and adolescence. J Clin Endocrinol Metab 1994;79:1135–1140.

    PubMed  CAS  Google Scholar 

  18. Nyhan WL, Green M. Hyperthyroidism in a patient with a pituitary adenoma. J Pediatr 1964;65:583–589.

    PubMed  CAS  Google Scholar 

  19. Avramides A, Karapiperis A, Triantafyllidou E, Vayas S, Moshidou A, Vyzantiadis A. TSH-secreting pituitary macroadenoma in an 11-year-old girl. Acta Paediatr 1992;81:1058–1060.

    PubMed  CAS  Google Scholar 

  20. Suntornlohanakul S, Vasiknanont P, Mo-Suwan L, Phuenpathom N, Chongchitnant N. TSH secreting pituitary adenoma in children: a case report. J Med Assoc Thai 1990;73:175–178.

    PubMed  CAS  Google Scholar 

  21. Bickler SW, McMahon TJ, Campbell JR, Mandel S, Piatt JH, Harrison MW. Preoperative diagnostic evaluation of children with Cushing’s syndrome. J Pediatr Surg 1994;29:671–676.

    PubMed  CAS  Google Scholar 

  22. Trainer PJ, Grossman A. The diagnosis and differential diagnosis of Cushing’s syndrome. Clin Endocrinol (Oxford) 1991;34:317–330.

    CAS  Google Scholar 

  23. Magiakou MA, Mastorakos G, Oldfield EH, Gomez MT, Doppman JL, Cutler GB Jr, et al. Cushing’ s syndrome in children and adolescents. Presentation, diagnosis, and therapy. N Engl J Med 1994;331: 629–636.

    PubMed  CAS  Google Scholar 

  24. Mindermann T, Wilson CB. Pituitary adenomas in childhood and adolescence. J Pediatr Endocrinol Metab 1995;8:79–83.

    PubMed  CAS  Google Scholar 

  25. Weber A, Trainer PJ, Grossman AB, Afshar F, Medbak S, Perry LA, et al. Investigation, management and therapeutic outcome in 12 cases of childhood and adolescent Cushing’s syndrome. Clin Endocrinol (Oxford) 1995;43:19–28.

    CAS  Google Scholar 

  26. Styne DM, Grumbach MM, Kaplan SL, Wilson CB, Conte FA. Treatment of Cushing’s disease in childhood and adolescence by transsphenoidal microadenomectomy. N Engl J Med 1984;310: 889–893.

    PubMed  CAS  Google Scholar 

  27. Gelber SJ, Heffez DS, Donohoue PA. Pituitary gigantism caused by growth hormone excess from infancy. J Pediatr 1992;120:931–934.

    PubMed  CAS  Google Scholar 

  28. Blumberg DL, Sklar CA, David R, Rothenberg S, Bell J. Acromegaly in an infant. Pediatrics 1989;83:998–1002.

    PubMed  CAS  Google Scholar 

  29. Geffner ME, Nagel RA, Dietrich RB, Kaplan SA. Treatment of acromegaly with a somatostatin analog in a patient with McCune- Albright syndrome. J Pediatr 1987;111: 740–743.

    PubMed  CAS  Google Scholar 

  30. Kovacs K, Horvath E, Thorner MO, Rogol AD. Mammosoma-totroph hyperplasia associated with acromegaly and hyperpro-lactinemia in a patient with the McCune-Albright syndrome: a histologic, immunocytologic and ultrastructural study of the surgically-removed adenohypophysis. Virchows Arch A Pathol Anat Histopathol 1984;403:77–86.

    PubMed  CAS  Google Scholar 

  31. Polychronakos C, Tsoukas G, Ducharme JR, Letarte J, Collu R. Gigantism and hyperprolactinemia in polyostotic fibrous dysplasia (Mc Cune-Albright syndrome). J Endocrinol Invest 1982;5:323–326.

    PubMed  CAS  Google Scholar 

  32. Moran A, Asa SL, Kovacs K, Horvath E, Singer W, Sagman U, et al. Gigantism due to pituitary mammosomatotroph hyperplasia. N Engl J Med 1990;323:322–327.

    PubMed  CAS  Google Scholar 

  33. Asa SL, Kovacs K, Horvath E, Losinski NE, Laszlo FA, Domokos I, et al. Human fetal adenohypophysis. Electron microscopic and ultrastructural immunocytochemical analysis. Neuroendocrinology 1988;48:423–431.

    PubMed  CAS  Google Scholar 

  34. Sano T, Asa SL, Kovacs K. Growth hormone-releasing hormone- producing tumors: clinical, biochemical, and morphological manifestations. Endocr Rev 1988;9:357–373.

    PubMed  CAS  Google Scholar 

  35. Aron DC, Tyrrell JB, Wilson CB. Pituitary tumors. Current concepts in diagnosis and management. West J Med 1995;162:340–352.

    PubMed  CAS  Google Scholar 

  36. Sippell WG, Dorr HG, Bidlingmaier F, Knorr D. Plasma levels of aldosterone, corticosterone, 11-deoxycorticosterone, progesterone, 17-hydroxyprogesterone, cortisol, and cortisone during infancy and childhood. Pediatr Res 1980;14:39–46.

    PubMed  CAS  Google Scholar 

  37. Franks RC. Diurnal variation of plasma 17-hydroxycorticosteroids in children. J Clin Endocrinol Metab 1967;27:75–78.

    PubMed  CAS  Google Scholar 

  38. Arafah BM, Kailani S, Selman WR. Physiology and pathophysiology of prolactin secretion. In: Barrow DL, Selman WR, eds. Neuroendocrinology. Williams and Wilkins, Baltimore, 1992, pp. 95–112.

    Google Scholar 

  39. Cox TD, Elster AD. Normal pituitary gland: changes in shape, size, and signal intensity during the 1st year of life at MR imaging. Radiology 1991;179:721–724.

    PubMed  CAS  Google Scholar 

  40. Kucharczyk J, Kucharczyk W, Berry I, de Groot J, Kelly W, Norman D, et al. Histochemical characterization and functional significance of the hyperintense signal on MR images of the posterior pituitary. AJR 1989;152:153–157.

    PubMed  CAS  Google Scholar 

  41. Colombo N, Berry I, Kucharczyk J, Kucharczyk W, de Groot J, Larson T, et al. Posterior pituitary gland: appearance on MR images in normal and pathologic states. Radiology 1987;165:481–485.

    PubMed  CAS  Google Scholar 

  42. Kucharczyk W, Davis DO, Kelly WM, Sze G, Norman D, Newton TH. Pituitary adenomas: high-resolution MR imaging at 1.5 T. Radiology 1986;161:761–765.

    PubMed  CAS  Google Scholar 

  43. Elster AD. Modern imaging of the pituitary. Radiology 1993; 187:1–14.

    PubMed  CAS  Google Scholar 

  44. Chong BW, Kucharczyk W, Singer W, George S. Pituitary gland MR: a comparative study of healthy volunteers and patients with microadenomas. AJNR 1994;15:675–679.

    PubMed  CAS  Google Scholar 

  45. Snow RB, Johnson CE, Morgello S, Lavyne MH, Patterson RH Jr. Is magnetic resonance imaging useful in guiding the operative approach to large pituitary tumors? Neurosurgery 1990;26:801–803.

    PubMed  CAS  Google Scholar 

  46. Stein AL, Levenick MN, Kletzky OA. Computed tomography versus magnetic resonance imaging for the evaluation of suspected pituitary adenomas. Obstet Gynecol 1989;73:996–999.

    PubMed  CAS  Google Scholar 

  47. Davis PC, Hoffman JC Jr, Spencer T, Tindall GT, Braun IF. MR imaging of pituitary adenoma: CT, clinical, and surgical correlation. AJR 1987;148:797–802.

    PubMed  CAS  Google Scholar 

  48. Newton DR, Dillon WP, Norman D, Newton TH, Wilson CB. Gd-DTPA-enhanced MR imaging of pituitary adenomas. AJNR 1989;10:949–954.

    PubMed  CAS  Google Scholar 

  49. Stadnik T, Stevenaert A, Beckers A, Luypaert R, Buisseret T, Oxteaux M. Pituitary microadenomas: diagnosis with two-and three-dimensional MR imaging at 1.5 T before and after injection of gadolinium. Radiology 1990;176:419–428.

    PubMed  CAS  Google Scholar 

  50. Ludecke DK, Herrmann HD, Schulte FJ. Special problems with neurosurgical treatments of hormone-secreting pituitary adenomas in children. Prog Exp Tumor Res 1987;30:362–370.

    PubMed  CAS  Google Scholar 

  51. Oldfield EH, Chrousos GP, Schulte HM, Schaaf M, McKeever PE, Krudy AG, et al. Preoperative lateralization of ACTH- secreting pituitary microadenomas by bilateral and simultaneous inferior petrosal venous sinus sampling. N Engl J Med 1985;312: 100–103.

    PubMed  CAS  Google Scholar 

  52. Cunnah D, Besser M. Management of prolactinomas. Clin Endocrinol (Oxford) 1991;34:231–235.

    CAS  Google Scholar 

  53. Molitch ME, Elton RL, Blackwell RE, Caldwell B, Chang RJ, Jaffe R, et al. Bromocriptine as primary therapy for prolactin-secreting macroadenomas: results of a prospective multicenter study. J Clin Endocrinol Metab 1985;60:698–705.

    PubMed  CAS  Google Scholar 

  54. Tyson D, Reggiardo D, Sklar C, David R. Prolactin-secreting macroadenomas in adolescents. Response to bromocriptine therapy. Am J Dis Child 1993;147:1057–1061.

    PubMed  CAS  Google Scholar 

  55. Arslanian SA, Becker DJ, Lee PA, Drash AL, Foley TP Jr. Growth hormone therapy and tumor recurrence. Findings in children with brain neoplasms and hypopituitarism. Am J Dis Child 1985;139: 347–350.

    PubMed  CAS  Google Scholar 

  56. Clayton PE, Shalet SM, Gattamaneni HR, Price DA. Does growth hormone cause relapse of brain tumours? Lancet 1987;1:711–713.

    PubMed  CAS  Google Scholar 

  57. Oberfield SE, Nino M, Riddick L, Pang S, Nagel M, Khandji A, et al. Combined bromocriptine and growth hormone (GH) treatment in GH-deficient children with macroprolactinoma in situ. J Clin Endocrinol Metab 1992;75:87–90.

    PubMed  CAS  Google Scholar 

  58. Fraioli B, Ferrante L, Celli P. Pituitary adenomas with onset during puberty. Features and treatment. J Neurosurg 1983;59:590–595.

    PubMed  CAS  Google Scholar 

  59. Gaini SM, Giovanelli M, Forni C, Villani R, Scuccimarra A, Carteri A, et al. Pituitary adenomas in infancy and childhood. Mod Probl Paediatr 1976;18:220–225.

    PubMed  CAS  Google Scholar 

  60. Ortiz-Suarez H, Erickson DL. Pituitary adenomas of adolescents. J Neurosurg 1975;43:437–439.

    PubMed  CAS  Google Scholar 

  61. Maira G, Anile C. Pituitary adenomas in childhood and adolescence. Can J Neurol Sci 1990;17:83–87.

    PubMed  CAS  Google Scholar 

  62. Leinung MC, Kane LA, Scheithauer BW, Carpenter PC, Laws ER Jr, Zimmerman D. Long term follow-up of transsphenoidal surgery for the treatment of Cushing’s disease in childhood. J Clin Endocrinol Metab 1995;80:2475–2479.

    PubMed  CAS  Google Scholar 

  63. Ross DA, Wilson CB. Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. J Neurosurg 1988;68:854–867.

    PubMed  CAS  Google Scholar 

  64. Tindall GT, Oyesiku NM, Watts NB, Clark RV, Christy JH, Adams DA. Transsphenoidal adenomectomy for growth hormone-secreting pituitary adenomas in acromegaly: outcome analysis and determinants of failure. J Neurosurg 1993;78:205–215.

    PubMed  CAS  Google Scholar 

  65. Rorke LB. Introductory survey of brain tumors. In: Cheek WR, ed. Pediatric Neurosurgery. W. B. Saunders, Philadelphia, 1994, pp. 351–355.

    Google Scholar 

  66. Epstein FJ, Handler MH. Craniopharyngioma: the answer. Pediatr Neurosurg 1994;21(Suppl 1):S 1–S 132.

    Google Scholar 

  67. Carmel PW, Antunes JL, Chang CH. Craniopharyngiomas in children. Neurosurgery 1982;11:382–389.

    PubMed  CAS  Google Scholar 

  68. Hoffman HJ, De Silva M, Humphreys RP, Drake JM, Smith ML, Blaser SI. Aggressive surgical management of craniopharyngiomas in children. J Neurosurg 1992;76:47–52.

    PubMed  CAS  Google Scholar 

  69. Carmel PW. Brain tumors of disordered embryogenesis. In: Youmans JR, ed. Neurological Surgery. W. B. Saunders, Philadelphia, 1996, pp. 2761–2781.

    Google Scholar 

  70. Adamson TE, Wiestler OD, Kleihues P, Yasargil MG. Correlation of clinical and pathological features in surgically treated craniopharyngiomas. J Neurosurg 1990;73:12–17.

    PubMed  CAS  Google Scholar 

  71. Banna M. Craniopharyngioma in adults. Surg Neurol 1973; 1:202–204.

    PubMed  CAS  Google Scholar 

  72. Burger PC, Scheithauer BW, Vogel FS. Surgical Pathology of Nervous System and Its Coverings, 3rd ed. Churchhill Livingston, New York, 1991.

    Google Scholar 

  73. Giangaspero F, Burger PC, Osborne DR, Stein RB. Suprasellar papillary squamous epithelioma (“papillary craniopharyngioma”). Am J Surg Pathol 1984;8:57–64.

    PubMed  CAS  Google Scholar 

  74. Petito CK, DeGirolami U, Earle KM. Craniopharyngiomas: a clinical and pathological review. Cancer 1976;37:1944–1952.

    PubMed  CAS  Google Scholar 

  75. Weiner HL, Wisoff JH, Rosenberg ME, Kupersmith MJ, Cohen H, Zagzag D, et al. Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery 1994;35:1001–1010.

    PubMed  CAS  Google Scholar 

  76. Kahn EA, Gosch HH, Seeger JF, Hicks SP. Forty-five years experience with the craniopharyngiomas. Surg Neurol 1973;1:5–12.

    PubMed  CAS  Google Scholar 

  77. Hoffman HJ, Kestle J. Craniopharyngiomas. In: Cheek WR, ed. Pediatric Neurosurgery. W. B. Saunders, Philadelphia, 1994, pp. 418–428.

    Google Scholar 

  78. Baskin DS, Wilson CB. Surgical management of craniopharyngiomas. A review of 74 cases. J Neurosurg 1986;65:22–27.

    PubMed  CAS  Google Scholar 

  79. Pusey E, Kortman KE, Flannigan BD, Tsuruda J, Bradley WG. MR of craniopharyngiomas: tumor delineation and characterization. AJR 1987;149:383–388.

    PubMed  CAS  Google Scholar 

  80. Harrison MJ, Morgello S, Post KD. Epithelial cystic lesions of the sellar and parasellar region: a continuum of ectodermal derivatives? J Neurosurg 1994;80:1018–1025.

    PubMed  CAS  Google Scholar 

  81. Matson DD, Crigler JFJ. Management of craniopharyngioma in childhood. J Neurosurg 1969;30:377–399.

    PubMed  CAS  Google Scholar 

  82. Wen DY, Seljeskog EL, Haines SJ. Microsurgical management of craniopharyngiomas. Br J Neurosurg 1992;6:467–474.

    PubMed  CAS  Google Scholar 

  83. Yasargil MG, Curcic M, Kis M, Siegenthaler G, Teddy PJ, Roth P. Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients. J Neurosurg 1990;73:3–11.

    PubMed  CAS  Google Scholar 

  84. Carpenter RC, Chamberlin GW, Frazier CH. The treatment of hypophyseal stalk tumors by evacuation and irradiation. AJR 1937;38:162–177.

    Google Scholar 

  85. Regine WF, Kramer S. Pediatric craniopharyngiomas: long term results of combined treatment with surgery and radiation. Int J Radiat Oncol Biol Phys 1992;24:611–617.

    PubMed  CAS  Google Scholar 

  86. Regine WF, Mohiuddin M, Kramer S. Long-term results of pediatric and adult craniopharyngiomas treated with combined surgery and radiation. Radiother Oncol 1993;27:13–21.

    PubMed  CAS  Google Scholar 

  87. Danoff BF, Cowchock FS, Kramer S. Childhood craniopharyngioma: survival, local control, endocrine and neurologic function following radiotherapy. Int J Radiat Oncol Biol Phys 1983;9:171–175.

    PubMed  CAS  Google Scholar 

  88. Wen BC, Hussey DH, Staples J, Hitchon PW, Jani SK, Vigliotti AP, et al. A comparison of the roles of surgery and radiation therapy in the management of craniopharyngiomas. Int J Radiat Oncol Biol Phys 1989;16:17–24.

    PubMed  CAS  Google Scholar 

  89. Weiss M, Sutton L, Marcial V, Fowble B, Packer R, Zimmerman R, et al. The role of radiation therapy in the management of childhood craniopharyngioma. Int J Radiat Oncol Biol Phys 1989; 17:1313–1321.

    PubMed  CAS  Google Scholar 

  90. Manaka S, Teramoto A, Takakura K. The efficacy of radiotherapy for craniopharyngioma. J Neurosurg 1985;62:648–656.

    PubMed  CAS  Google Scholar 

  91. Fischer EG, Welch K, Shillito J Jr, Winston KR, Tarbell NJ. Craniopharyngiomas in children. Long-term effects of conservative surgical procedures combined with radiation therapy. J Neurosurg 1990;73:534–540.

    PubMed  CAS  Google Scholar 

  92. Wisoff JH. Surgical management of recurrent craniopharyngiomas. Pediatr Neurosurg 1994;21(Suppl 1):108–113.

    PubMed  Google Scholar 

  93. Maira G, Anile C, Rossi GF, Colosimo C. Surgical treatment of craniopharyngiomas: an evaluation of the transsphenoidal and pterional approaches. Neurosurgery 1995;36:715–724.

    PubMed  CAS  Google Scholar 

  94. Laws ERJ. Transsphenoidal removal of craniopharyngioma. Pediatr Neurosurg 1994;21(Suppl 1):57–63.

    PubMed  Google Scholar 

  95. Takahashi H, Nakazawa S, Shimura T. Evaluation of postoperative intratumoral injection of bleomycin for craniopharyngioma in children. J Neurosurg 1985;62:120–127.

    PubMed  CAS  Google Scholar 

  96. Broggi G, Franzini A, Cajola L, Pluchino F. Cell kinetic investigations in craniopharyngioma: preliminary results and considerations. Pediatr Neurosurg 1994;21(Suppl 1):21–23.

    PubMed  Google Scholar 

  97. Broggi G, Giorgi C, Franzini A, Servello D, Solero CL. Preliminary results of intracavitary treatment of craniopharyngioma with bleomycin. J Neurosurg Sci 1989;33:145–148.

    PubMed  CAS  Google Scholar 

  98. Hoffman HJ. Surgical management of craniopharyngioma. Pediatr Neurosurg 1994;21 (Suppl 1):44–49.

    PubMed  Google Scholar 

  99. Haisa T, Ueki K, Yoshida S. Toxic effects of bleomycin on the hypothalamus following its administration into a cystic craniopharyngioma. Br J Neurosurg 1994;8:747–750.

    PubMed  CAS  Google Scholar 

  100. Lunsford LD, Pollock BE, Kondziolka DS, Levine G, Flickinger JC. Stereotactic options in the management of craniopharyngioma. Pediatr Neurosurg 1994;21(Suppl 1):90–97.

    PubMed  Google Scholar 

  101. Pollock BE, Lunsford LD, Kondziolka D, Levine G, Flickinger JC. Phosphorus-32 intracavitary irradiation of cystic craniopharyngiomas: current technique and long-term results. Int J Radiat Oncol Biol Phys 1995;33:437–446.

    PubMed  CAS  Google Scholar 

  102. Listernick R, Charrow J, Greenwald MJ, Esterly NB. Optic gliomas in children with neurofibromatosis type 1. J Pediatr 1989; 114:788–792.

    PubMed  CAS  Google Scholar 

  103. Cohen ME, Duffner PK. Optic pathway tumors. Neurol Clin 1991;9:467–477.

    PubMed  CAS  Google Scholar 

  104. Hoffman HJ, Humphreys RP, Drake JM, Rutka JT, Becker LE, Jenkin D, et al. Optic pathway/hypothalamic gliomas: a dilemma in management. Pediatr Neurosurg 1993;19:186–195.

    PubMed  CAS  Google Scholar 

  105. Johnson DL, McCullough DC. Optic nerve gliomas and other tumors involving the optic nerve and chiasm. In: Cheek WR, ed. Pediatric Neurosurgery. W. B. Saunders, Philadelphia, 1994, pp. 409–417

    Google Scholar 

  106. Rodriguez LA, Edwards MS, Levin VA. Management of hypothalamic gliomas in children: an analysis of 33 cases. Neurosurgery 1990;26:242–246.

    PubMed  CAS  Google Scholar 

  107. DeSousa AL, Kalsbeck JE, Mealey J Jr, Ellis FD, Muller J. Optic chiasmatic glioma in children. Am J Ophthalmol 1979;87:376–381.

    PubMed  CAS  Google Scholar 

  108. Pierce SM, Barnes PD, Loeffler JS, McGinn C, Tarbell NJ. Definitive radiation therapy in the management of symptomatic patients with optic glioma. Survival and long-term effects. Cancer 1990; 65:45–52.

    PubMed  CAS  Google Scholar 

  109. Packer RJ, Sutton LN, Bilaniuk LT, Radcliffe J, Rosenstock JG, Siegel KR, et al. Treatment of chiasmatic/hypothalamic gliomas of childhood with chemotherapy: an update. Ann Neurol 1988; 23:79–85.

    PubMed  CAS  Google Scholar 

  110. Venes JL, Latack J, Kandt RS. Postoperative regression of opticochiasmatic astrocytoma: a case for expectant therapy. Neurosurgery 1984;15:421–423.

    PubMed  CAS  Google Scholar 

  111. Nishio S, Takeshita I, Fujiwara S, Fukui M. Optico-hypothalamic glioma: an analysis of 16 cases. Childs Nery Syst 1993;9:334–338.

    CAS  Google Scholar 

  112. Kovalic JJ, Grigsby PW, Shepard MJ, Fineberg BB, Thomas PR. Radiation therapy for gliomas of the optic nerve and chiasm. Int J Radiat Oncol Biol Phys 1990;18:927–932.

    PubMed  CAS  Google Scholar 

  113. Danoff BF, Kramer S, Thompson N. The radiotherapeutic management of optic nerve gliomas in children. Int J Radiat Oncol Biol Phys 1980;6:45–50.

    PubMed  CAS  Google Scholar 

  114. Flickinger JC, Torres C, Deutsch M. Management of low-grade gliomas of the optic nerve and chiasm. Cancer 1988;61:635–642.

    PubMed  CAS  Google Scholar 

  115. Rowland JH, Glidewell OJ, Sibley RF, Holland JC, Tull R, Berman A, et al. Effects of different forms of central nervous system prophylaxis on neuropsychologic function in childhood leukemia. J Clin Oncol 1984;2:1327–1335.

    PubMed  CAS  Google Scholar 

  116. Copeland DR, Fletcher JM, Pfefferbaum-Levine B, Jaffe N, Ried H, Maor M. Neuropsychological sequelae of childhood cancer in longterm survivors. Pediatrics 1985;75:745–753.

    PubMed  CAS  Google Scholar 

  117. Duffner PK, Cohen ME. The long-term effects of central nervous system therapy on children with brain tumors. Neurol Clin 1991; 9:479–495.

    PubMed  CAS  Google Scholar 

  118. Duffner PK, Cohen ME. Long-term consequences of CNS treatment for childhood cancer, Part II: Clinical consequences. Pediatr Neurol 1991;7:237–242.

    PubMed  CAS  Google Scholar 

  119. Cohen ME, Duffner PK. Long-term consequences of CNS treatment for childhood cancer, Part I: Pathologic consequences and potential for oncogenesis. Pediatr Neurol 1991;7:157–163.

    PubMed  CAS  Google Scholar 

  120. Duffner PK, Cohen ME, Thomas P. Late effects of treatment on the intelligence of children with posterior fossa tumors. Cancer 1983;51:233–237.

    PubMed  CAS  Google Scholar 

  121. Hirsch JF, Renier D, Czernichow P, Benveniste L, Pierre-Kahn A. Medulloblastoma in childhood. Survival and functional results. Acta Neurochir (Wien) 1979;48:1–15.

    CAS  Google Scholar 

  122. Raimondi AJ, Tomita T. Medulloblastoma in childhood: comparative results of partial and total resection. Childs Brain 1979;5:310–328.

    PubMed  CAS  Google Scholar 

  123. Roman DD, Sperduto PW. Neuropsychological effects of cranial radiation: current knowledge and future directions. Int J Radiat Oncol Biol Phys 1995;31:983–998.

    PubMed  CAS  Google Scholar 

  124. Schultheiss TE, Kun LE, Ang KK, Stephens LC. Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys 1995;31:1093–1112.

    PubMed  CAS  Google Scholar 

  125. Packer RJ, Savino PJ, Bilaniuk LT, Zimmerman RA, Schatz NJ, Rosenstock JG, et al. Chiasmatic gliomas of childhood. A reappraisal of natural history and effectiveness of cranial irradiation. Childs Brain 1983;10:393–403.

    PubMed  CAS  Google Scholar 

  126. Moghrabi A, Friedman HS, Burger PC, Tien R, Oakes WJ. Carboplatin treatment of progressive optic pathway gliomas to delay radiotherapy. J Neurosurg 1993;79:223–227.

    PubMed  CAS  Google Scholar 

  127. Janss AJ, Grundy R, Cnaan A, Savino PJ, Packer RJ, Zackai EH, et al. Optic pathway and hypothalamic/chiasmatic gliomas in children younger than age 5 years with a 6-year follow-up. Cancer 1995;75: 1051–1059.

    PubMed  CAS  Google Scholar 

  128. Chamberlain MC, Grafe MR. Recurrent chiasmatic-hypothalamic glioma treated with oral etoposide. J Clin Oncol 1995;13: 2072–2076.

    PubMed  CAS  Google Scholar 

  129. Petronio J, Edwards MS, Prados M, Freyberger S, Rabbitt J, Silver P, et al. Management of chiasmal and hypothalamic gliomas of infancy and childhood with chemotherapy. J Neurosurg 1991; 74:701–708.

    PubMed  CAS  Google Scholar 

  130. Duffner PK, Horowitz ME, Krischer JP, Friedman HS, Burger PC, Cohen ME, et al. Postoperative chemotherapy and delayed radiation in children less than three years of age with malignant brain tumors. N Engl J Med 1993;328:1725–1731.

    PubMed  CAS  Google Scholar 

  131. Jennings MT, Gelman R, Hochberg F. Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg 1985;63:155–167.

    PubMed  CAS  Google Scholar 

  132. Hoffman HJ, Otsubo H, Hendrick EB, Humphreys RP, Drake JM, Becker LE, et al. Intracranial germ-cell tumors in children. J Neurosurg 1991;74:545–551.

    PubMed  CAS  Google Scholar 

  133. Sklar CA, Grumbach MM, Kaplan SL, Conte FA. Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: report of 10 patients. J Clin Endocrinol Metab 1981;52:9–16.

    PubMed  CAS  Google Scholar 

  134. Fujimaki T, Matsutani M, Funada N, Kirino T, Takakura K, Nakamura O, et al. CT and MRI features of intracranial germ cell tumors. J Neurooncol 1994;19:217–226.

    PubMed  CAS  Google Scholar 

  135. Tien RD, Barkovich AJ, Edwards MS. MR imaging of pineal Otumors. AJR 1990;155:143–151.

    PubMed  CAS  Google Scholar 

  136. Wolden SL, Wara WM, Larson DA, Prados MD, Edwards MS, Sneed PK. Radiation therapy for primary intracranial germ-cell tumors. Int J Radiat Oncol Biol Phys 1995;32:943–949.

    PubMed  CAS  Google Scholar 

  137. Rengachary SS, Watanabe I. Ultrastructure and pathogenesis of intracranial arachnoid cysts. J Neuropathol Exp Neurol 1981; 40:61–83.

    PubMed  CAS  Google Scholar 

  138. Smith RA, Smith WA. Arachnoid cysts of the middle cranial fossa. Surg Neurol 1976;5:246–252.

    PubMed  CAS  Google Scholar 

  139. Go KG, Houthoff HJ, Blaauw EH, Havinga P, Hartsuiker J. Arachnoid cysts of the sylvian fissure. Evidence of fluid secretion. J Neurosurg 1984;60:803–813.

    PubMed  CAS  Google Scholar 

  140. Pierre-Kahn A, Capelle L, Brauner R, Sainte-Rose C, Renier D, Rappaport R, et al. Presentation and management of suprasellar arachnoid cysts. Review of 20 cases. J Neurosurg 1990;73: 355–359.

    PubMed  CAS  Google Scholar 

  141. Galassi E, Piazza G, Gaist G, Frank F. Arachnoid cysts of the middle cranial fossa: a clinical and radiological study of 25 cases treated surgically. Surg Neurol 1980;14:211–219.

    PubMed  CAS  Google Scholar 

  142. Raffel C, McComb JG. To shunt or to fenestrate: which is the best surgical treatment for arachnoid cysts in pediatric patients? Neurosurgery 1988;23:338–342.

    PubMed  CAS  Google Scholar 

  143. Ciricillo SF, Cogen PH, Harsh GR, Edwards MS. Intracranial arachnoid cysts in children. A comparison of the effects of fenestration and shunting. J Neurosurg 1991;74:230–235.

    PubMed  CAS  Google Scholar 

  144. Voelker JL, Campbell RL, Muller J. Clinical, radiographic, and pathological features of symptomatic Rathke’s cleft cysts. J Neurosurg 1991;74:535–544.

    PubMed  CAS  Google Scholar 

  145. Kucharczyk W, Peck WW, Kelly WM, Norman D, Newton TH. Rathke cleft cysts: CT, MR imaging, and pathologic features. Radiology 1987;165:491–495.

    PubMed  CAS  Google Scholar 

  146. Whyte AM, Sage MR, Brophy BP. Imaging of large Rathke’s cleft cysts by CT and MRI: report of two cases. Neuroradiology 1993;35:258–260.

    PubMed  CAS  Google Scholar 

  147. Oka H, Kawano N, Suwa T, Yada K, Kan S, Kameya T. Radiological study of symptomatic Rathke’s cleft cysts. Neurosurgery 1994;35:632–636.

    PubMed  CAS  Google Scholar 

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Authors
  1. Nalin Gupta MD, PhD
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  2. James T. Rutka MD, PhD
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Editor information

Editors and Affiliations

  1. Division of Neurosurgery, Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada

    Kamal Thapar MD, PhD

  2. Department of Pathology and Laboratory Medicine, St. Michael’s Hospital, Toronto, Ontario, Canada

    Kalman Kovacs MD, PhD

  3. Department of Pathology, Mayo Clinic, Rochester, MN, USA

    Bernd W. Scheithauer MD  & Ricardo V. Lloyd MD, PhD  & 

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© 2001 Springer Science+Business Media New York

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Gupta, N., Rutka, J.T. (2001). Pituitary Tumors in Children. In: Thapar, K., Kovacs, K., Scheithauer, B.W., Lloyd, R.V. (eds) Diagnosis and Management of Pituitary Tumors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-217-3_21

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  • DOI: https://doi.org/10.1007/978-1-59259-217-3_21

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9693-2

  • Online ISBN: 978-1-59259-217-3

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