Skip to main content

Positron Emission Tomography in Sellar Tumors

In Vivo Metabolic, Receptor, and Enzyme Characterization

  • Chapter
  • 224 Accesses

Abstract

Positron emission tomography (PET) is now a well-recognized technique for research as well as clinical practice. The PET technique has been in use for more than 20 years in a wide range of scientific areas and now has also proven to be of great value in clinical practice. We have used the PET technique for 16 years to investigate intracranial tumors and especially sellar tumors of which pituitary adenomas are the most common tumor type. PET has been used to characterize in vivo these tumors with respect to metabolism, receptor properties, and enzyme content like. The characterization has been used for diagnosing and outlining the tumors, in differential diagnostic perspective, and in the follow-up of treatment (1,2).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Muhr C, Bergstrom M. Positron emission tomography applied in the study of pituitary adenomas. J Endocrinol Invest 1991;14:509–528.

    PubMed  CAS  Google Scholar 

  2. Muhr C. Positron emission tomography (PET) in pituitary adenomas. In: Landolt AM, Reilly PL, Vance ML, eds. Pituitary Adenomas. Churchill Livingstone, Medical Division of Longman Group UK Ltd, 1996, pp. 229–238.

    Google Scholar 

  3. Muhr C, Bergstrom M, Lundberg P-O, Bergstrom K, Hartvig P, Lundqvist H, et al. Dopamine receptors in pituitary adenomas: PET visualization with C-11-N-methylspiperone. J Comput Assist Tomogr 1986;10:175–180.

    Article  PubMed  CAS  Google Scholar 

  4. Muhr C, Bergstrom M, Lundberg PO, Bergstrom K, Laångström B. In vivo measurement of dopamine receptors in pituitary adenomas using positron emission tomography. Acta Radiol. Proceedings: Symposium Neuroradiologicum 1986.

    Google Scholar 

  5. Muhr C, Bergstrom M, Lundberg P O, Hartman M, Bergstrom K, Pelletieri L, et al. Malignant prolactinoma with multiple intracranial metastases studied with positron emission tomography. Neurosurgery 1988;22:374–379.

    Article  PubMed  CAS  Google Scholar 

  6. Benker G, Gieshoff B, Freundlieb O, Windeck R, Schulte H M, Lancranjan I, et al. Parenteral bromocriptine in the treatment of hormonally active pituitary tumors. Clin Endocrinol 1986;24: 505–513.

    Article  CAS  Google Scholar 

  7. Lundin P, Bergstrom K, Nyman R, Lundberg PO, Muhr C. Macroprolactinomas: Serial MR imaging in long-term bromocriptine therapy. AJNR 1992;13:1279–1291.

    PubMed  CAS  Google Scholar 

  8. Raymond JP, Goldstein E, Konopka P, Leleu MF, Merceron RE, Loria Y. Follow up of children born of bromocriptine-treated mothers. Hormone Res 1985;22:239–246.

    Article  PubMed  CAS  Google Scholar 

  9. Bergstrom M, Muhr C, Lundberg PO, Bergstrom K, Lundqvist H, Antoni G, et al. In vivo study of amino acid distribution and metabolism in pituitary adenomas using positron emission tomography with 11C-D-methionine and 11C-L-methionine. J Comput Assist Tomogr 1987;11:384–389.

    Article  PubMed  CAS  Google Scholar 

  10. Bergstrom M, Muhr C, Lundberg P O, Bergstrom K, Gee A D, Fasth K-G, et al. Rapid decrease in amino acid metabolism in prolactin-secreting pituitary adenomas after bromocriptine treatment—a PET study. J Comput Assist Tomogr 1987;11:815–819.

    Article  PubMed  CAS  Google Scholar 

  11. Muhr C. PET in endocrinology. In: Higgins CB, Auffermann W, eds. Endocrine Imaging. Thieme Medical Publishers, New York, 1994, pp. 344–352.

    Google Scholar 

  12. Bergstrom M, Muhr C, Lundberg PO, Jossan S, Gati I, Lilja A, et al. Differentiation of pituitary adenoma an meningioma: visualization with positron emission tomography and 11C-deprenyl. Neurosurgery 1992;30:855–861.

    Article  PubMed  CAS  Google Scholar 

  13. Nyberg G, Bergstrom M, Enblad P, Lilja A, Muhr C, Laångström B. PET-Methionine of Skull Base Neuromas and Meningiomas. Acta Otolaryngol 1997;117:482–489.

    Article  PubMed  CAS  Google Scholar 

  14. Di Chiro G, Oldfield E, Wright DC, de Michele D, Katz DA, Patronas NJ, et al. Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropatho-logic studies. Am J Roentgenol 1988;150:189–197.

    Google Scholar 

  15. Delbecke D, Meyerowitz C, Lapidus RL, Maciunas RJ, Jennings MT, Moots PL, et al. Optimal cutoff levels of F-18 fluoro-deoxyglucose uptake in the differentiation of low-grade from high-grade brain tumours with PET. Radiology 1995;195:47–52.

    Google Scholar 

  16. Di Chiro G, Hatazawa J, Katz DA, Rizzoli HV, de Michele D. Glucose utilization by intracranial meningiomas as an index of tumor aggressivity and probability of recurrence: a PET study. Radiology 1987;164:521–526.

    PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer Science+Business Media New York

About this chapter

Cite this chapter

Muhr, C. (2001). Positron Emission Tomography in Sellar Tumors. In: Thapar, K., Kovacs, K., Scheithauer, B.W., Lloyd, R.V. (eds) Diagnosis and Management of Pituitary Tumors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-217-3_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-217-3_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9693-2

  • Online ISBN: 978-1-59259-217-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics