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Pituitary Adenomas

Historic Considerations

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Diagnosis and Management of Pituitary Tumors

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Abstract

Pierre Marie’s report on acromegaly in 1886 opened an era of interest in pituitary tumors and renewed inquiry into the function of the pituitary gland (1). Prior to that time, abnormalities of the pituitary had been infrequently recorded. Landolt wrote that Plater in 1641 described a 24-yr-old man with progressive loss of vision, convulsions, and weakness (2). Postmortem examination revealed a pituitary tumor the size of a hen’s egg. Rolleston in his book, The Endocrine Organs in Health and Disease (3), noted that Bonet in 1679 and Wepfer in 1681 reported enlargement of the pituitary, Vieussens in 1705 documented enlargement of the pituitary with blindness, and Gray and Ward in 1849 each reported a tumor of the pituitary to the Pathological Society of London. Ward’s patient, a young woman who had experienced progressive loss of vision, was at postmortem found to have a large pituitary tumor also involving the infundibulum and pressing on the optic nerves (4). Gray’s patient was a 30-yr-old woman with headaches and confusion. At postmortem examination, her pituitary was “large,” as was the sella, which contained pus, and communicated with the pharynx (5). Earlier, in 1823, Ward published his findings in a 38-yr-old male who for 3 yr had failing vision and, in the last days

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Authors
  1. Raymond V. Randall MD, MS
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  2. Bernd W. Scheithauer MD
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  3. Kalman Kovacs MD, PhD, DSc
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Editors and Affiliations

  1. Division of Neurosurgery, Department of Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada

    Kamal Thapar MD, PhD

  2. Department of Pathology and Laboratory Medicine, St. Michael’s Hospital, Toronto, Ontario, Canada

    Kalman Kovacs MD, PhD

  3. Department of Pathology, Mayo Clinic, Rochester, MN, USA

    Bernd W. Scheithauer MD  & Ricardo V. Lloyd MD, PhD  & 

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Randall, R.V., Scheithauer, B.W., Kovacs, K. (2001). Pituitary Adenomas. In: Thapar, K., Kovacs, K., Scheithauer, B.W., Lloyd, R.V. (eds) Diagnosis and Management of Pituitary Tumors. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-217-3_1

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  • DOI: https://doi.org/10.1007/978-1-59259-217-3_1

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