Skip to main content

Basic Biology of Hemopoiesis

  • Chapter
Book cover Modern Hematology

Part of the book series: Contemporary Hematology ((CH))

  • 145 Accesses

Abstract

The formation of blood cells (hemopoiesis) is determined by the interaction of multiple genes, and involves cytokines and other protein factors. The relative ease with which hematopoietic cells can be studied and the development of new techniques in cell biology have enabled us to understand many of the factors determining cell renewal and differentiation. Based on this knowledge, major progress has been made in the last 15 yr in the treatment and diagnosis of many hematologic disorders. In this chapter, we describe the cell types involved in normal hematopoiesis and their interactions with one another. Furthermore, the basic techniques necessary for the study of hematopoietic cells in the normal and pathologic state are outlined.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  • Banchereau J, Steinman RM. Dendritic cells and the control of immunity. Nature 1998; 392: 245–252.

    Article  PubMed  CAS  Google Scholar 

  • Burrows PD, Cooper MD. B cell development and differentiation. Curr Opin Immunol 1997; 9: 239–244.

    Article  PubMed  CAS  Google Scholar 

  • Cross MA, Enver T. The lineage commitment of haemopoietic progenitor cells. Curr Opin Gen Dey 1997; 7: 609–613.

    Article  CAS  Google Scholar 

  • Gewirtz AM. Megakaryocytopoiesis: the state of the art. Thromb Haemost 1995; 74: 204–209.

    PubMed  CAS  Google Scholar 

  • Hsia CCW. Respiratory function of hemoglobin. N Engl J Med 1998; 338: 239–247.

    Article  PubMed  CAS  Google Scholar 

  • Janeway CA, Travers P. Immunobiology, in The Immune System in Health and Disease, 3rd ed. New York and London: Garland, 1997.

    Google Scholar 

  • Migliaccio AR, Migliaccio G. The making of an erythroid cell. Molecular control of erythropoiesis. Biotherapy 1998; 10: 251–268.

    Article  PubMed  CAS  Google Scholar 

  • Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood 1993; 81: 2844–2853.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer Science+Business Media New York

About this chapter

Cite this chapter

Munker, R., Hiller, E., Paquette, R. (2000). Basic Biology of Hemopoiesis. In: Modern Hematology. Contemporary Hematology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-203-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-203-6_1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-5873-3

  • Online ISBN: 978-1-59259-203-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics