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CCKA Receptors in Gastrointestinal Disorders

New Therapeutic Implications

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Drug Development

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Abstract

Knowledge of the pathophysiological roles of gastrointestinal (GI) peptides has progressed with the advances in peptide chemistry. However, a decisive step has been the development of potent and specific peptide receptor antagonists, which not only became important experimental tools for elucidating the physiological roles of peptide hormones, but also in defining the contribution of peptide hormones to disease states, but they may even ultimately prove to be important as therapeutic agents. Among all GI peptides, nonpeptidic molecules with potent and selective antagonistic properties have been made available for gastrin and cholecystokinin (CCK). Comprehensive reviews on the biological actions of CCK (Mutt, 1980; Morley, 1982; Crawley and Vanderhaeghen, 1985; Albus, 1988; Brawley 1991; Hökfelt et al., 1991; Moran and McHugh, 1991; Smith and Gibbs, 1992; Crawley and Corvin 1994; Walsh, 1994a, 1994b) and on CCK receptors (Dourish and Hill, 1987; Jensen et al., 1990; Woodruff and Hughes, 1991; Silvente-Poirot et al., 1993; Williams and Blevins, 1993; D’ Amato et al., 1994; Rasmussen, 1995; Wang, 1995) are available. Moreover, Adler and Beglinger (1991), provide comprehensive coverage of the role of CCK in the control of GI functions with the use of CCK antagonists.

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Authors
  1. Massimo D’Amato
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  2. Francesco Makovec
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  3. Lucio C. Rovati
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Editors and Affiliations

  1. School of Pharmacy, University of Wisconsin, Madison, WI, USA

    Timothy S. Gaginella

  2. Parke-Davis Pharmaceutical Research Division, Ann Arbor, MI, USA

    Antonio Guglietta

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D’Amato, M., Makovec, F., Rovati, L.C. (2000). CCKA Receptors in Gastrointestinal Disorders. In: Gaginella, T.S., Guglietta, A. (eds) Drug Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-202-9_6

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  • DOI: https://doi.org/10.1007/978-1-59259-202-9_6

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