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The Spinal Cat

  • Chapter
Neurobiology of Spinal Cord Injury

Part of the book series: Contemporary Neuroscience ((CNEURO))

Abstract

A number of reviews have summarized important insights on the role played by various nervous system structures in the control of locomotion (1–8). These reviews have also highlighted the remarkable locomotor capacities of the spinal cord after a complete spinal transection, which removes all the ascending and descending pathways normally exerting important control over spinal cord functions. The purpose of this chapter is to focus specifically on the locomotor capabilities of the spinal cat, not so much to show that “spinal” locomotion resembles “normal” locomotion but rather to illustrate the extent to which the spinal cord can express and adapt its locomotor functions in the absence of these regulatory mechanisms. Does this spinal behavior represent the contribution of the spinal cord to normal locomotion? Probably not, because in all pathologic conditions, the central nervous system utilizes whatever circuitry is available to optimize its functions. It is possible that some mechanisms are less important in the normal cat but become essential for locomotion after spinalization, such as some sensory afferents. Thus, a better understanding of the “physiopathology” of locomotion after spinal cord injury in animal models is important both in highlighting some of the principles that may help understand normal locomotion and in increasing our understanding of some of the mechanisms of recovery of a motor function following a spinal trauma. Such knowledge is important for improving the design of various types of therapeutic approaches in spinal-cord-injured patients (9,10).

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Authors
  1. Serge Rossignol
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  2. Marc Bélanger
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  3. Connie Chau
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  4. Nathalie Giroux
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  5. Edna Brustein
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  7. Claude-André Grenier
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  8. Trevor Drew
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  9. Hughes Barbeau
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  10. Tomas A. Reader
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Editors and Affiliations

  1. Departments of Neurology and Pharmacology, Yale University School of Medicine, New Haven, CT, USA

    Robert G. Kalb MD

  2. Department of Neurology, Yale University School of Medicine, New Haven, CT, USA

    Stephen M. Strittmatter MD, PhD

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Rossignol, S. et al. (2000). The Spinal Cat. In: Kalb, R.G., Strittmatter, S.M. (eds) Neurobiology of Spinal Cord Injury. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-200-5_3

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  • DOI: https://doi.org/10.1007/978-1-59259-200-5_3

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