Abstract
Follicular carcinomas are rather rare in the industrialized nations today (1,2). They do not have the nuclear features of papillary carcinoma, usually have no papillae, lack amyloid and calcitonin, and do not contain the numerous spindle cells, giant cells, and mitotic figures of undifferentiated (anaplastic) carcinoma. Most published classifications are based upon the degree of invasiveness of the cancer, but histological patterns of the neoplasm also may provide clues to likely behavior (3). At present, evaluating the relationship of the neoplasm to the surrounding tissues has proved to be the most useful guide to categorizing these tumors (4–7).
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References
Franssila KO, Ackerman LV, Brown CL, Hedinger CE. Follicular carcinoma. Semin Diagn Pathol 1985; 2: 101–122.
LiVolsi VA. Surgical pathology of the thyroid. Major Probl Pathol 1990; 22: 173–212.
Mueller-Gaertner H-W, Brzac HT, Rehpenning W. Prognostic indices for tumor relapse and tumor mortality in follicular thyroid carcinoma. Cancer 1991; 67: 1903–1911.
Lang W, Georgii A, Stauch G, Kienzle E. The differentiation of atypical adenomas and encapsulated follicular carcinomas in the thyroid gland. Virchows Arch A Pathol Mat Histopathol 1980; 385: 125–141.
Kahn NF, Perzin KH. Follicular carcinoma of the thyroid: an evaluation of the histologic criteria used for diagnosis. Pathol Annu 1983; 18 (Part 1): 221–253.
Lang W, Choritz H, Hundeshagen H. Risk factors in follicular thyroid carcinomas: a retrospective follow-up study covering a 14-year period with emphasis on morphological findings. Am J Surg Pathol 1986; 10: 246–255.
Hoie J, Stenwig AE. Long-term survival in patients with follicular thyroid carcinoma—the Oslo experience: variations with encapsulation, growth pattern, time of diagnosis, sex, age, and previous thyroid surgery. J Surg Oncol 1992; 49: 226–230.
Rosai J, Carcangiu ML, DeLellis RA. Tumors of the thyroid gland. In Rosai J, Sobin LH, editors. Atlas of tumor pathology, 3rd Ser, Fasc 5. Washington, DC: A.F.I.P., 1992.
Evans HL. Follicular neoplasms of the thyroid: a study of 44 cases followed for a minimum of 10 years, with emphasis on differential diagnosis. Cancer 1984; 54: 535–540.
Yamashita T, Fujimoto Y, Kodama T, et al. When is total thyroidectomy indicated as a treatment of “follicular carcinoma”? World J Surg 1988; 12: 559–564.
Grebe SKG, Hay ID. Follicular thyroid cancer. Endocrinol Metab Clin North Am 1995; 24: 761–801.
Yamashina M. Follicular neoplasms of the thyroid. Total circumferential evaluation of the fibrous capsule. Am J Surg Pathol 1992; 16: 392–400.
van Heerden JA, Hay ID, Goellner JR, et al. Follicular thyroid carcinoma with capsular invasion alone: a nonthreatening malignancy. Surgery 1992; 112: 1130–1138.
Hazard JB, Kenyon R. Atypical adenoma of the thyroid. Arch Pathol Lab Med 1954; 58: 554–563.
Jorda M, Gonzalez-Campora R, Mora J, Herrero-Zapatero A, Otal C, Galera H. Prognostic factors in follicular carcinoma of the thyroid. Arch Pathol Lab Med 1993; 117: 631–635.
Harach HR, Franssila KO. Thyroglobulin immunostaining in follicular thyroid carcinoma: relationship to the degree of differentiation and cell type. Histopathology 1988; 13: 43–54.
Schröder S, Pfannschmidt N, Dralle H, Arps H, Böcker W. The encapsulated follicular carcinoma of the thyroid: a clinicopathologic study of 35 cases. Virchows Arch A Pathol Anat Histopathol 1984; 402: 259–273.
Schröder S. Pathological and clinical features of malignant thyroid tumors: Classification, immunohistology, prognostic criteria. New York: Gustav Fischer, 1988.
Segal K, Arad A, Lubin E, Shpitzer T, Hadar T, Feinmesser R. Follicular carcinoma of the thyroid. Head Neck 1994; 16: 533–538.
Grant CS, Hay ID, Ryan JJ, Bergstralh EJ, Rainwater LM, Goellner JR. Diagnostic and prognostic utility of flow cytometric DNA measurements in follicular thyroid tumors. World J Surg 1990; 14: 283–290.
Oyama T, Vickery Jr AL, Preffer FI, Colvin RB. A comparative study of flow cytometry and histopathologic findings in thyroid follicular carcinomas and adenomas. Hum Pathol 1994; 25: 271–275.
Hruban RH, Huvos AG, Traganos F, Reuter V, Lieberman PH, Melamed MR. Follicular neoplasms of the thyroid in men older than 50 years of age: a DNA flow cytometric study. Am J Clin Pathol 1990; 94: 527–532.
Rüschoff J, Prasser C, Cortez T, Höhne HM, Hohenberger W, Hofstädter F. Diagnostic value of AgNOR staining in follicular cell neoplasms of the thyroid: comparison of evaluation methods and nucleolar features. Am J Surg Pathol 1993; 17: 1281–1288.
Shem-Tov Y, Straus M, Talmi YP, Rath-Wolfsom L, Zohar Y, Gal R. Nucleolar organizer regions in follicular tumors of the thyroid. Head Neck 1994; 16: 420–423.
Droese M. Cytological aspiration biopsy of the thyroid gland, 1st ed. Translated by A. Burt. Stuttgart: FK Schattauer, 1980.
Grant CS, Barr D, Goellner JR, Hay ID. Benign Wirthle cell tumors of the thyroid: a diagnosis to be trusted? World J Surg 1988; 12: 488–495.
Bronner MP, LiVolsi VA. Oxyphilic (Askanazy/Hürthle cell) tumors of the thyroid: microscopic features predict biologic behavior. Surg Pathol 1988; 1: 137–150.
Carcangiu ML, Bianchi S, Savino D, Voynick IM, Rosai J. Follicular Hürthle cell tumors of the thyroid gland. Cancer 1991; 68: 1944–1953.
Tateyama H, Yang Y-P, Eimoto T, et al. Proliferative cell nuclear antigen expression in follicular tumours of the thyroid with special reference to oxyphilic cell lesions. Virchows Arch A Pathol Anat Histopathol 1994; 424: 533–537.
Ryan JJ, Hay ID, Grant CS, Rainwater LM, Farrow GM, Goellner JR. Flow cytometric DNA measurements in benign and malignant Hürthle cell tumors of the thyroid. World J Surg 1988; 12: 482–487.
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Oertel, J., Oertel, Y. (2000). Pathology of Follicular Cancer. In: Wartofsky, L. (eds) Thyroid Cancer. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-199-2_28
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DOI: https://doi.org/10.1007/978-1-59259-199-2_28
Publisher Name: Humana Press, Totowa, NJ
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