Skip to main content

Radioiodine Therapy of Thyroid Cancer

General Considerations — I

  • Chapter
Thyroid Cancer

Abstract

Differentiated thyroid cancer, when it has the ability to concentrate radioactive iodine, lends itself nicely to postthyroidectomy radioiodine therapy (Fig. 1). The term radioiodine therapy is used to designate the treatment of residual recurrent, or metastatic thyroid cancer (1–6). Radioiodine ablation, on the other hand, is used to describe the removal of noncancerous thyroid tissue, particularly that which is left after thyroidectomy. The distinction between these terms is frequently blurred, for when thyroid cancer has been diagnosed, and near-total thyroidectomy performed, one cannot assume that there is no residual cancer. Many thyroid cancers are multicentric (8–10). Others show evidence of extrathyroidal extension or capsular penetration. It may be prudent to consider that residual thyroid cancer is present (4) and that treatment is not complete until all vestiges of thyroid tissue are gone.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Beierwaltes WH, Rabbani R, Dmuchowski C, et al. An analysis of “ablation of thyroid remnants” with I-131 in 511 patients from 1947–1984: experience at University of Michigan. J Nucl Med 1984–1993; 25: 1287–1293.

    Google Scholar 

  2. Freitas JE, Gross MD, Ripley S, et al. Radionuclide diagnosis and therapy of thyroid cancer: current status report. Semin Nucl Med 1985; 15: 106–131.

    Article  CAS  PubMed  Google Scholar 

  3. Harbert JC. Radioiodine therapy of differentiated thyroid carcinoma. In: Nuclear medicine therapy. New York: Thieme, 1987.

    Google Scholar 

  4. Hurley JR, Becker DV. Treatment of thyroid carcinoma with radioiodine. In Gottschalk A, Hoffer PB, Potchen EJ, Berger HJ, editors. Diagnostic nuclear medicine, 2nd ed. Baltimore: Williams and Wilkins, 1988: 792.

    Google Scholar 

  5. Leeper RD, Shimaoka K. Treatment of metastatic thyroid cancer. Clin Endocrinol Metab 1980; 9: 383.

    Article  CAS  PubMed  Google Scholar 

  6. Maxon HR, Smith HR. Radioiodine-131 in the diagnosis and treatment of metastatic well-differentiated thyroid cancer. Endocrinol Metab Clin North Am 1990; 19: 685–718.

    PubMed  Google Scholar 

  7. Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 1994; 97: 418–28.

    Article  CAS  PubMed  Google Scholar 

  8. Clark OH, Levin K, Zeng Q, et al. Thyroid cancer: the case for total thyroidectomy. Eur J Cancer Clin Oncol 1988; 24: 305–13.

    Article  CAS  PubMed  Google Scholar 

  9. Tollefsen HR, DeCosse JJ, Hutter RVP. Papillary carcinoma of the thyroid: a clinical and pathological study of j70 fatal cases. Cancer 1964; 17: 1035.

    Article  CAS  PubMed  Google Scholar 

  10. Clark RL, White E, Russell WO. Total thyroidectomy for cancer of the thyroid. Ann Surg 1959; 149: 858.

    Article  PubMed  Google Scholar 

  11. Ronga G, Fiorentino A, Paserio E, et al. Can iodine-131 whole body scan be replaced by thyroglobulin measurement in the postsurgical follow-up of differentiated thyroid carcinoma? J Nucl Med 1990; 31: 1766.

    CAS  PubMed  Google Scholar 

  12. Sisson JC. Applying the radioactive eraser: 131I to ablate normal thyroid tissue in patients from whom thyroid cancer has been resected. J Nucl Med 1983; 24: 743.

    CAS  PubMed  Google Scholar 

  13. Iida Y, Hidaka A, Hatabu H, et al. Follow-up study of postoperative patients with thyroid cancer by thallium-201 scintigraphy and serum thyroglobulin measurement. J Nucl Med 1991; 32: 2098.

    Google Scholar 

  14. Pacini F, Lippi F, Formica N, et al. Therapeutic doses of iodine-131 reveal undiagnosed metastases in thyroid cancer patients with detectable serum thyroglobulin levels. J Nucl Med 1987; 28: 1888.

    CAS  PubMed  Google Scholar 

  15. Ramanna L, Waxman A, Braunstein G. Thallium-201 scintigraphy in differentiated thyroid cancer: comparison with radioiodine scintigraphy and serum thyroglobulin determination. J Nucl Med 1991; 32: 441.

    CAS  PubMed  Google Scholar 

  16. Schlumberger M. Can iodine-131 whole-body scan be replaced by thyroglobulin measurement in the postsurgical follow-up of differentiated thyroid carcinoma? J Nucl Med 1992; 33: 172.

    CAS  PubMed  Google Scholar 

  17. Kuni CC, Klingensmith WC III. Failure of low doses of 131I to ablation residual thyroid tissue following surgery for thyroid cancer. Radiology 1980; 137: 773–774.

    CAS  PubMed  Google Scholar 

  18. Commtois R, Theriault C, Del Vecchio P. Assessment of the efficacy of iodine-131 for thyroid ablation. J Nucl Med 1993; 34: 1927–1930.

    Google Scholar 

  19. McCowan KD, Adler RA, Ghaed N, et al. Low-dose radioiodide thyroid ablation in postsurgical patients with thyroid cancer. Am J Med 1976; 61: 52.

    Article  Google Scholar 

  20. Rawson RW, Rall JE, Peacock W. Limitations and indications in the treatment of cancer of the thyroid with radioactive iodine. J Clin Endocrinol 1951; 11: 1128.

    Article  CAS  Google Scholar 

  21. Allen HC Jr, Zielinski JD. 480 Non-hospitalized thyroid cancer patients treated with single doses 50–400mCi [Abstract]. J Nucl Med 1990; 31:784.

    Google Scholar 

  22. Davis NL, Gordon M, German E, et al. Efficacy of I-131 ablation following thyroidectomy in patients with invasive follicular thyroid cancer. Am J Surg 1992; 163: 472.

    Article  CAS  PubMed  Google Scholar 

  23. Cady B, Rossi R. An expanded view of risk group definition in differentiated thyroid carcinoma. Surgery 1988; 104: 947–953.

    CAS  PubMed  Google Scholar 

  24. Samaan NA, Schultz PN, Hickey R, et al. The results of various modalities of treatment of well-differentiated thyroid carcinoma: a retrospective review of 1599 patients. J Clin Endocrinol Metab 1992; 75: 714–720.

    Article  CAS  PubMed  Google Scholar 

  25. Arad E, O’Mara RE, Wilson GA. Ablation of remaining functioning thyroid lobe with radioiodine after hemithyroidectomy for carcinoma. Clin Nucl Med 1993; 18: 662–663.

    Article  CAS  PubMed  Google Scholar 

  26. Clark OH, Hoelting T. Management of patients with differentiated thyroid cancer who have positive serum thyroglobulin levels and negative radioiodine scans. Thyroid 1994; 4: 501.

    Article  CAS  PubMed  Google Scholar 

  27. Pineda JD, Lee T, Reynolds J, et al. 131-I therapy for thyroid cancer with elevated thyroglobulin and negative diagnostic scan [Abstract]. Thyroid 1992; 2: S16.

    Google Scholar 

  28. Robbins J (moderator). Thyroid cancer: a lethal endocrine neoplasm. Ann Intern Med 1991; 115: 133.

    CAS  PubMed  Google Scholar 

  29. U.S. Nuclear Regulatory Commission. Release of individuals containing radiopharmaceuticals or permanent implants. In: Part 35. Medical use of byproduct material. Washington, DC: U.S. Regulatory Commission, 1997: Paragraph 35. 75, 3516.

    Google Scholar 

  30. Culver CM, Dworkin HJ: Radiation safety considerations for post-iodine-131 thyroid cancer therapy. J Nucl Med 1992; 33: 1402.

    CAS  PubMed  Google Scholar 

  31. U.S. Nuclear Regulatory Commission. Regulatory guide 8.39: Release of patients administered radioactive material. Washington, DC: U.S. Nuclear Regulatory Commission, April 1997.

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer Science+Business Media New York

About this chapter

Cite this chapter

Johnston, G., Sweeney, D. (2000). Radioiodine Therapy of Thyroid Cancer. In: Wartofsky, L. (eds) Thyroid Cancer. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-199-2_12

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-199-2_12

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-6845-9

  • Online ISBN: 978-1-59259-199-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics