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Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies

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Book cover Xenotransplantation

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Abstract

The problem in transplanting pig organs to humans is the occurrence of hyperacute rejection. Natural antibodies (particularly IgM, but also IgG) bind to antigens on the endothelium lining the blood vessels, fix complement, and lead to endothelial cell activation and intravascular thrombosis within minutes. Hyperacute rejection can be prevented by the depletion, blocking, or removal of any of the three components. Here we examine the importance of carbohydrate antigens in xenograft rejection, in particular the Galα(1,3)Gal epitope; the α1,3galactosyltransferase enzyme responsible for generating Galα(1,3)Gal and transgenic strategies designed to eliminate or reduce expression of Galα(1,3)Gal, such that the epitope can no longer be detected by natural human antibodies.

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Authors
  1. Mauro S. Sandrin PhD, DSc
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  2. Ian F. C. McKenzie MD, PhD
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Editors and Affiliations

  1. Transplantation Biology and the Departments of Surgery, Immunology, and Pediatrics, Mayo Clinic, Rochester, MN, USA

    Jeffrey L. Platt MD

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Sandrin, M.S., McKenzie, I.F.C. (2002). Synthesis of Carbohydrate Antigens Recognized by Xenoreactive Antibodies. In: Platt, J.L. (eds) Xenotransplantation. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-166-4_7

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  • DOI: https://doi.org/10.1007/978-1-59259-166-4_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-127-1

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