Abstract
The idea of transplanting animal organs into patients with organ failure is not new. When the development of vascular anastomosis made organ transplantation feasible from a surgical perspective, a few clinical renal xenografts were attempted. In 1906, Jaboulay (1) described the xenotransplantation of pig and goat grafts into humans. Neither pig nor goat grafts functioned, and the failure of the xenograft did not allow vascular thrombosis to be observed. At the same time, Unger performed xenotransplantation using organs from nonhuman primates with similar results (2). In 1923, Harol Neuhof affirmed that thrombosis or hemorrhage in the xenotransplant could be prevented (2). However, technical imperfection and the lack of understanding of immunological host reactivity led to waning interest in xenotransplantation.
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Bustos, M., Platt, J.L. (2002). Pathological Responses to Xenotransplantation. In: Platt, J.L. (eds) Xenotransplantation. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-166-4_2
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DOI: https://doi.org/10.1007/978-1-59259-166-4_2
Publisher Name: Humana Press, Totowa, NJ
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