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Antibody-Dependent Effects on Cellular Immunity

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Xenotransplantation

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Abstract

Transplantation of tissues or organs between different species is referred to as Xenotransplantation. Combinations of donor and recipient species in which a xenograft is rapidly lost due to hyperacute rejection (HAR) are operationally defined as “discordant,” whereas combinations in which HAR does not occur are called “concordant.” HAR is initiated by binding of xenogeneic natural antibodies (XNA) to the vascular endothelial cells (VEC) of the implanted discordant xenogeneic organ. The presence of XNA in the recipient therefore defines a discordant species combination.

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Authors
  1. Antonello Pileggi
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  2. R. Damaris Molano
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  3. Thierry Berney
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  4. Luca Inverardi MD
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Editors and Affiliations

  1. Transplantation Biology and the Departments of Surgery, Immunology, and Pediatrics, Mayo Clinic, Rochester, MN, USA

    Jeffrey L. Platt MD

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Pileggi, A., Molano, R.D., Berney, T., Inverardi, L. (2002). Antibody-Dependent Effects on Cellular Immunity. In: Platt, J.L. (eds) Xenotransplantation. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-166-4_10

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  • DOI: https://doi.org/10.1007/978-1-59259-166-4_10

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