Abstract
The research to be described in this chapter has followed a distinctively different historical path than most neurotoxic research, and this is because of the underlying goals that have guided it. A fundamental question is why one would study the neurotoxic effects of drugs of abuse. One obvious answer is because this is an issue of great relevance to society. Another is because most of the closest models of mental disorders such as schizophrenia, or compulsive disorders, or depression, are based on drug models from addicts. This leads to the hope that understanding the effects of addiction will shed light on many other psychopathologies as well.
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References
Ellison, G. D. and Eison, M. S. (1983) Continuous amphetamine intoxication: an animal model of the acute psychotic episode. Psychol. Med. 13, 751–761.
Ellison, G. (1991) Animal models of hallucinations: continuous stimulants, in Neuromethods, vol 18: Animal Models in Psychiatry (Boulton, A., Baker, G., and Martin-Iverson, M., eds.), pp. 151–196.
Ellison, G. (1994) Stimulant-induced psychosis, the dopamine theory, and the habenula. Brain Res. Rev. 19, 223–239.
Connell, P. (1958) Amphetamine Psychosis. Maudsley Monographs No. 5. Oxford University Press, London.
Bell, D. (1965) Comparison of amphetamine psychosis and schizophrenia. Am. J. Psychiatry 111, 701–707.
Ellinwood, E. H. Jr., (1967) Amphetamine psychosis: I. Description of the individuals and the process. J. Nerv. Mental Dis. 144, 273–283.
Siegal, R. K. (1977) Cocaine: recreational use and intoxication, in NIDA Research Monograph 13 ( Petersen, R. C. and Stillman, R. C., eds.), US Government Printing Office, Washington, DC.
Lesko, L. M., Fischman, M., Javaid, J., and Davis, J. (1982) Iatrogenous cocaine psychosis. N. Engl. J. Med. 307, 1153–1156.
Gawin, F. H. (1986) Neuroleptic reduction of cocaine-induced paranoia but not euphoria? Psychopharmacology 90, 142–143.
Manschreck, T. C., Laughery, J. A., Weisstein, C. C., Allen, D., Humblestone, B., Neville, M., et al. (1988) Characteristics of freebase cocaine psychosis. Yale J. Biol. Med. 61, 115–122.
Brady, K., Lydiard, R., Malcolm, R., and Ballenger, J. (1991) Cocaine-induced psychosis. J. Clin. Psychiatry 52, 509–512.
Elpern, D. (1988) Cocaine abuse and delusions of parasitosis. Cutis 42, 273–274.
Mitchell, J. and Vierkant, A. (1991) Delusions and hallucinations of cocaine abusers and paranoid schizophrenics: a comparative study. J. Psychiatry 125, 301–310.
Kramer, J. C., Gischman, V., and Littlefield, D. (1967) Amphetamine abuse: pattern and effects of high doses taken intravenously. J. Am. Med. Assoc. 201, 89–93.
Griffith, J., Cavanaugh, J., Held, N., and Oates, J. (1972) D-amphetamine: evaluation of psychotomimetic properties in man. Arch. Gen. Psychiatry 26, 97–100.
Bell, D. (1973) The experimental reproduction of amphetamine psychosis. Arch. Gen. Psychiatry 29, 35–40.
Satel, S., Southwick, S., and Gawin, F., (1992) Clinical features of cocaine-induced paranoia. Am. J. Psychiatry 148, 495–498.
Ellison, G. and Morris, W. (1981) Opposed stages of continuous amphetamine administration: parallel alterations in motor sterotypies and in vivo spiroperidol accumulation. Eur. J. Pharmacol. 74, 207–214.
Ellison, G. D., Eison, M. S., and Huberman, H. (1978b) Stages of constant amphetamine intoxication: delayed appearance of abnormal social behaviors in rat colonies. Psychopharmacology 56, 293–299.
Ellison, G. D., Nielsen, E. B., and Lyon, M. (1981) Animal models of psychosis: hallucinatory behaviors in monkeys during the late stage of continuous amphetamine intoxication. J. Psychiatry Res. 16, 13–22.
Nielsen, E., Lee, T., and Ellison, G. (1980b) Following several days of continuous administration d-amphetamine acquires hallucinogen-like properties. Psychopharmacology 68, 197–200.
de Leon, J., Antelo, R., and Simpson, G. (1992) Delusion of parasitosis or chronic hallucinosis: hypothesis about their brain physiopathology. Compr. Psychiatry 33, 25–33.
Nielsen, E. B., Neilsen, M., Ellison, G., and Braestrup, E. (1980a) Decreased spiroperidol and LSD binding in rat brain after continuous amphetamine. Eur. J. Pharmacol. 66, 149–154.
Ellison, G. D., Eison, M., Huberman, H., and Daniel, F. (1978a) Long term changes in dopaminergic innervation of caudate nucleus after continuous amphetamine administration. Science 201, 276–278.
Nwanze, E. and Jonsson, G. (1981) Amphetamine neurotoxicity on dopamine nerve terminals in the caudate nucleus of mice. Neurosci. Lett. 26, 163–168
Ryan, L., Martone, M., Linder, J., and Groves, P. (1990) Histological and ultrastructural evidence that d-amphetamine causes degeneration in neostriatum and frontal cortex of rats. Brain Res. 518, 67–77.
Ryan, L. J., Martone, M., Linder, J., and Groves, P. M. (1988) Cocaine, in contrast to d-amphetamine, does not cause axonal terminal degeneration in neostriatum and agranular frontal cortex of long-evans rats. Life Sci. 43, 1403–1409.
Hotchkiss, A. and Gibb, J. (1980) Long-term effects of multiple doses of methamphetamine on tryptophan hydroxylase and tyrosine hydroxylase activity in rat brain. J. Pharmacol. Exp. Ther. 214, 257–262.
Ricaurte, G. A., Schuster, C. R., and Seiden, L. S. (1980) Long-term effects of repeated methylamphetamine administration on dopamine and serotonin neurons in the rat brain: a regional study. Brain Res. 193, 153–163.
Steranka, L. and Sanders-Bush, E. (1980) Long-term effects of continuous exposure to amphetamine on brain dopamine concentration and synaptosomal uptake in mice. Eur. J. Pharmacol. 65, 439–443.
Fuller, R. and Hemrick-Luecke, S. (1980) Long-lasting depletion of striatal dopamine by a single injection of amphetamine in iprindole-treated rats. Science 209, 305–306.
Wagner, G., Lucot, J., Chuster, C., and Seiden, L. (1983) Alpha-methyltyrosine attenuates and reserpine increases methamphetamine-induced neuronal changes. Brain Res. 270, 285–288.
Fuller, R. and Hemrick-Luecke, S. (1982) Further studies on the long-term depletion of striatal dopamine in iprindole-treated rats by amphetamine. Neuropharmacology 21, 433–438.
Hanson, G. R., Matsuda, L., and Gibb, J. W. (1987) Effects of cocaine on methamphetamine-induced neurochemical changes: characterization of cocaine as a monoamine uptake blocker. J. Pharmacol. Exp. Ther. 242, 507–513.
Sonsalla, P., Nicklas, W., and Heikkila, R. (1989) Role for excitatory amino acits in methamphetamine-induced nigrostriatal dopaminergic toxicity. Science 243, 398–400.
Fuller, R., Hemrick-Luecke, S., and Ornstein, P. (1992) Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist. Neuropharmacology 31, 1027–1032
Seiden, L. and Ricaurte, G. (1987) Neurotoxicity of methamphetamine and related drugs, in Psychopharmacology: The Third Generation of Progress ( Meltzer, H., ed.), Raven Press, New York, pp. 359–366.
Ellison, G. and Switzer, R. III (1996) Dissimilar patterns of degeneration in brain following four different addictive stimulants. NeuroReport 5, 17–20.
Lipton, J., Zeigler, S., Wilkins, J., and Ellison, G. (1991) Silicone pellet for continuous cocaine administration: heightened late-stage behaviors compared to continuous amphetamine. Pharmacol. Biochem. Behay. 38, 927–930.
Zeigler, S., Lipton, J., Toga, A., and Ellison, G. (1991) Continuous cocaine produces persistent changes in brain neurochemistry and behavior different from amphetamine. Brain Res. 552, 27–35.
Switzer, R. C. (1991) Strategies for assessing neurotoxicity. Neurosci. Biobehay. Rev. 15, 89–93.
de Olmos, J., Ebbesson, S., and Heimer, L. (1981) Silver methods for the impregnation of degenerating axoplasm, in Neuroanatomical Tract-tracing Methods ( Heimer, L. and Robards, N., eds.), Plenum Press, New York, pp. 117–168.
Ellison, G. (1992) Continuous amphetamine and cocaine have similar neurotoxic effects in lateral habenular nucleus and fasciculus retroflexus. Brain Res. 598, 353–356.
Herkenham, M. and Nauta, W. J. H. (1977) Afferent connections of the habenular nuclei in the rat. J. Comp. Neurol. 173, 123–146.
Herkenham, M. and Nauta, W. J. H. (1979) Efferent connections of the habenular nuclei in the rat. J. Comp. Neurol. 187, 19–48.
Sutherland, R. J. (1982) The dorsal diencephalic conduction system: a review of the anatomy and functions of the habenular complex. Neurosci. Biobehay. Rev. 6, 1–13.
London, E., Wilkerson, G., Goldberg, S., and Risner, M. (1986) Effects of L-cocaine on local cerebral glucose utilization in the rat. Neurosc. Lett. 68, 73–78.
Sasaki, K., Suda, H., Watanabe, H., and Yagi, H. (1990) Involvement of the entopeduncular nucleus and the habenula in methamphetamine-induced inhibition of dopamine neurons in the substantia nigra of rats. Brain Res. Bull. 25, 121–127.
Lisoprawski, A., Herve, D., Blanc, G., Glowinski, J., and Tassin, J. (1980) Selective activation of the mesocortico-frontal dopaminergic neurons induced by lesions of the habenula in the rat. Brain Res. 183, 229–234.
Nishikawa, T., Fage, D., and Scatton, B. (1986) Evidence for, and nature, of the tonic inhibitory influence of habenulointerpeduncular pathways upon cerebral dopaminergic transmission in the rat. Brain Res. 373, 324–336.
Christoph, C., Leonzio, R., and Wilcox, K. (1986) Stimulation of the lateral habenula inhibits dopamine-containing neurons in the substantia nigra and ventral tegmental area of the rat. J. Neurosci. 6, 613–619.
Keys, A. and Ellison, G. (1994) Continuous cocaine induces persisting alterations in dopamine overflow in caudate following perfusion with a D 1 agonist. J. Neur. Trans. Gen. Sect. 97, 225–233.
Corodimas, K., Rosenblatt, J., and Morrell, J. (1992) The habenular complex mediates hormonal stimulation of maternal behavior in rats. Behay. Neurosci. 106, 853–865
Ellison, G. D., Irwin, S., Keys, A., Noguchi, K., and Sulur, G. (1996) The neurotoxic effects of continuous cocaine and amphetamine in habenula: implications for the substrates of psychosis, in Neurotoxicity and Neuropathology Associated with Cocaine Abuse ( Majewska, M., ed.), NIDA Research Monograph, National Institute on Drug Abuse, Rockville MD, p. 163.
Araki, M., McGeer, P., and Kimura, H. (1988) The efferent projections of the rat lateral habenular nucleus revealed by the PHA-L anterograde tracing method. Brain Res. 441, 319–330.
Ellison, G. (1995) The NMDA antagonists phencyclidine, ketamine, and dizocilpine as both behavioral and anatomical models of the dementias. Brain Res. Rev. 20, 250–267.
Sharp, F., Sagar, S., and Swanson, R. (1993) Metabolic mapping with cellular resolution: c-fos vs. 2-deoxyglucose. Crit. Rev. Neurobiol. 679, 205–228.
Wirtshafter, D., Asin, K., and Pitzer, M. (1994) Dopamine agonists and stress produce different patterns of Fos-like immunoreactivity in the lateral habenula. Brain Res. 633, 21–26.
Keys, A. and Ellison, G. (1999) Long-term alterations in benzodiazepine, muscarinic and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor density following continuous cocaine administration. Pharmacol. Toxicol. 85, 144–150.
Meshul, C. K., Noguchi, K., Emire, N., and Ellison, G. (1998) Cocaine-induced changes in glutamate and GABA immunolabeling within rat habenula and nucleus accumbens. Synapse 30, 211–220.
Levin, E., Kim, P., Meray, R., Levin, E. D., Kim, P., and Meray, R. (1996) Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs. Psychopharmacology 127, 25–30.
Levin, E., Lee, C., Rose, J. E., Reyes, A., Ellison, G., Jarvik, M., and Gritz, E. (1990) Chronic nicotine and withdrawal effects on radial-arm maze performance in rats. Behay. Neural Biol. 53, 269–276.
Jias, L. M. and Ellison, G. (1990) Chronic nicotine induces a specific appetite for sucrose in rats. Pharmacol. Biochem. Behay. 35, 489–491.
Potthoff, A. D., Ellison, G., and Nelson, L. (1983) Ethanol intake increases during continuous administration of amphetamine and nicotine, but not several other drugs. Pharmacol. Biochem. Behay. 18, 489–493.
London, E. D., Waller, S. B., and Wamsley, J. K. (1985) Autoradiographic Localization of [3H]Nicotine Binding Sites in the Rat Brain. Neurosci. Lett. 53, 179–184.
Perry, D. C. and Kellar, K. J. (1995) [3H]Epibatidine labels nicotinic receptors in rat brain: an autoradiographic study. J. Pharmacol. Exp. Ther. 275, 1030–1034.
Wolinsky, T. D., Carr, K. D., Hiller, J. M., and Simon, E. J. (1994) Effects of chronic food restriction on mu and kappa opioid binding in rat forebrain: a quantitative autoradiographic study. Brain Res. 656, 274–280.
Thornton, E. W., Murray, M., Connors-Eckenrode, T., and Haun, F. (1994) Dissociation of behavioral changes in rats resulting from lesions of the habenula versus fasciculus retroflexus and their possible anatomical substrates. Behay. Neurosci. 108, 1150–1162.
Felton, T. M., Linton, L., Rosenblatt, J. S., and Morrell, J. I. (1998) Intact neurons of the lateral habenular nucleus are necessary for the nonhormonal, pup-mediated display of maternal behavior in sensitized virgin female rats. Behay. Neurosci. 112, 1458–1465.
Valjakka, A., Vartiainen, J., Tuomisto, L., Tuomisto, J. T., Olkkonen, H., and Airaksinen, M. M. (1998) The fasciculus retroflexus controls the integrity of rem sleep by supporting the generation of hippocampal theta rhythm and rapid eye movements in rats. Brain Res. Bull. 47, 171–184.
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Ellison, G. (2002). Studies of Neural Degeneration Indicate that Fasciculus Retroflexus Is a Weak Link in Brain for Many Drugs of Abuse. In: Massaro, E.J. (eds) Handbook of Neurotoxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-165-7_12
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DOI: https://doi.org/10.1007/978-1-59259-165-7_12
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