Breast Cancer pp 313-324 | Cite as

High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Breast Cancer

  • Edward A. Stadtmauer
Part of the Current Clinical Oncology book series (CCO)


The combination of surgery, radiation therapy, chemotherapy, and hormonal therapy has led to the cure of over 50% of patients with low stage breast cancer (1). Despite this success, however, most patients with locally advanced and metastatic disease will ultimately progress and succumb despite conventional dose therapy. By the mid-1980s, a strong relationship of dose to response, particularly for alkylating agents in breast cancer, had been demonstrated. The major dose-limiting toxicity was myelosuppression, and techniques of bone marrow and blood-derived stem cell harvesting, storage, and infusion allowed for the ready utilization of hematopoietic stem cells as support and rescue after high-dose therapy. The use of myeloid hematopoietic growth factors enhanced the collection of stem cells and marrow recovery after stem cell transplantation and allowed for rapid and reliable trilineage engraftment after high-dose chemotherapy.


Breast Cancer Stem Cell Transplantation Metastatic Breast Cancer Induction Chemotherapy Autologous Bone Marrow 
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© Springer Science+Business Media New York 2002

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  • Edward A. Stadtmauer

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