Skip to main content
SpringerLink
Log in

Sarcoma and Lymphoma of the Breast

Presentation, Diagnosis, and Treatment

  • Chapter
Book cover Breast Cancer

Part of the book series: Current Clinical Oncology ((CCO))

  • 177 Accesses

Abstract

Sarcomas arise from mesodermal structures. Common morphologic appearance and similar clinical patterns characterize these connective tissue tumors. The etiology is unknown, and most soft tissue sarcomas arise de novo. Soft tissue sarcomas expand radially and spread along paths of least resistance. Most develop pseudocapsules that contain tumor cells and therefore cannot be shelled out, as the risk of local recurrence is very high. Sarcomas rarely metastasize to regional lymph nodes. Hematogenous spread is common and occurs early. Pulmonary metastasis is often the first site of disseminated disease. Local recurrence is associated with disseminated disease in one-third of patients. The most important prognostic factors are histologic grade and size of tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. May DS, Stroup NE (1991) The incidence of sarcomas of the breast among women in the U.S, 1973–1986. Plast. Reconst. Surg. 87, 869–878.

    Article  Google Scholar 

  2. Page DL, Anderson TJ, Connelly JL, Schnitt SF (1987) Miscellaneous features of carcinoma. In: Page DL, Anderson TJ (eds.) Diagnostic Histopathology of the Breast. Churchill Livingstone, Edinburgh pp. 269–299.

    Google Scholar 

  3. Costa J, Wesley RA, Glatstein E, et al. (1984) The grading of soft tissue sarcoma. Results of clinicopathologic correlation in a series of 163 cases. Cancer 53, 530–541.

    Article  PubMed  CAS  Google Scholar 

  4. Russell WO, Cohen J, Enzinger F, et al. (1977) A clinical and pathological staging system for soft tissue sarcomas. Cancer 40, 1562–1570.

    Article  PubMed  CAS  Google Scholar 

  5. Gutman H, Pollock RE, Ross MI, et al. (1994) Sarcoma of the breast: implications for extent of therapy; the M.D. Anderson experience. Surgery 116, 505–509.

    PubMed  CAS  Google Scholar 

  6. Ciatto S, Bonardi R, Cataliotti L, et al. (1992) Sarcomas of the breast: a multicenter series of 70 cases. Neoplasma 39, 375–379.

    PubMed  CAS  Google Scholar 

  7. Smola MG, Ratschek M, Amann W, et al. (1993) The impact of resection margins in the treatment of primary sarcomas of the breast: a clinicopathological study of 8 cases with review of the literature. Eur. J. Surg. Oncol. 19, 61–69.

    PubMed  CAS  Google Scholar 

  8. Müller J (1838) Uber den feineran Bau and die Forman der krankhaften Geschwilste. G. Reimer, Berlin.

    Google Scholar 

  9. Dyer NH, Bridger JE, Taylor RS (1966) Cystosarcoma phylloides. Br. J. Surg. 53, 450–455.

    Article  PubMed  CAS  Google Scholar 

  10. Treves N (1964) A study of cystosarcoma phylloides. Ann. NYAcad. Sci. 114, 922–935.

    Article  Google Scholar 

  11. Hajdu S, Espinosa MH, Robbins GF (1976) Recurrent cystosarcoma phylloides-a clinicopathologic study of 32 cases. Cancer 38, 1402–1406.

    Article  PubMed  CAS  Google Scholar 

  12. McDivitt RW, Stewart FW, Berg JW (1968) Tumors of the breast. In: Atlas of Tumor Pathology, 2nd series, Fascicle 2. Armed Forces Institute of Pathology, Washington, DC.

    Google Scholar 

  13. Lee B, Pack G (1931) Giant intracanalicular fibroadenomyxoma of the breast. Am. J. Cancer 15, 2583–2595.

    Google Scholar 

  14. Hart WR, Bauer RC, Oberman HA (1978) Cystosarcoma phylloides. A clinicopathologic study of 26 hyper-cellular periductal stroma tumors of the breast. Am. J. Clin. Pathol. 70, 211–216.

    PubMed  CAS  Google Scholar 

  15. Pietrusz M, Barnes L (1978) Cystosarcoma phylloides. A clinicopathologic analysis of 42 cases. Cancer 41, 1974–1983.

    Article  Google Scholar 

  16. Kessinger A, Foley JF, Lemon HM, et al. (1972) Metastatic cystosarcoma phylloides: a case report and review of the literature. J. Surg. Oncol. 4, 131–145.

    Article  PubMed  CAS  Google Scholar 

  17. West L, Weiland LH, Clagett OT (1971) Cystosarcoma phylloides. Ann. Surg. 173, 520–528.

    Article  PubMed  CAS  Google Scholar 

  18. Givens SS, Ellerbroek NA, Butler JJ, et al. (1989) Angiosarcoma arising in an irradiated breast. A case report and review of the literature. Cancer 64, 2214–2216.

    Article  PubMed  CAS  Google Scholar 

  19. Edeiken SR, Russo DP, Knecht J, et al. (1992) Angiosarcoma after tylectomy and radiation therapy for carcinoma of the breast. Cancer 102, 757–763.

    Google Scholar 

  20. Moshaluk CA, Merino MJ, Danforth DN, et al. (1992) Low grade angiosarcoma of the skin of the breast: a complication of lumpectomy and radiation therapy for breast carcinoma. Hum. Pathol. 23, 710–714.

    Article  Google Scholar 

  21. Slotman BJ, van Hattum AH, Meyers S, et al. (1994) Angiosarcoma of the breast following conserving treatment for breast cancer. Eur. J. Cancer 30A, 416–417.

    Article  Google Scholar 

  22. Pendlebury SC, Bilous M, Langlands AO (1995) Sarcomas following radiation therapy for breast cancer: a report of three cases and a review of the literature. Int. J. Radiat. Oncol. Biol. Phys. 31, 405–410.

    Article  PubMed  CAS  Google Scholar 

  23. Zucali R, Merson M, Placucci M, et al. (1994) Soft tissue sarcoma of the breast after conservative surgery and irradiation for early mammary cancer. Radiother. Oncol. 30, 271–273.

    Article  PubMed  CAS  Google Scholar 

  24. Woodward AH, Ivins JC, Soule EH (1972) Lymphangiosarcoma arising in chronic lymphedematous extremities. Cancer 30, 562–572.

    Article  PubMed  CAS  Google Scholar 

  25. Brady MS, Garfein CF, Petrek JA, et al. (1994) Post-treatment sarcoma in breast cancer patients. Ann. Surg. Oncol. 1, 66–72.

    Article  PubMed  CAS  Google Scholar 

  26. Janse AJ, van Coevorden F, Peterse H, et al. (1995) Lymphedema-induced lymphangiosarcoma. Eur. J. Surg. Oncol. 21, 155–158.

    Article  PubMed  CAS  Google Scholar 

  27. Fineberg S, Rosen PP (1994) Angiosarcoma and atypical cutaneous lesions after radiation therapy for breast carcinoma. Am. J. Clin. Pathol. 102, 757–763.

    PubMed  CAS  Google Scholar 

  28. Brentani MM, Pacheco MM, Oshima CTF (1983) Steroid receptors in breast angiosarcoma. Cancer 51, 2105–2111.

    Article  PubMed  CAS  Google Scholar 

  29. Lesueur GC, Brown RW, Bhathal PS (1983) Incidence of perilobular hemangioma in the female breast. Arch. Pathol. Lab. Med. 107, 308–310.

    PubMed  CAS  Google Scholar 

  30. Steingaszner LC, Enzinger FM, Taylor HB (1965) Hemangiosarcoma of the breast. Cancer 18, 352–361.

    Article  PubMed  CAS  Google Scholar 

  31. Rosen PP, Kimmel M, Ernsberger DL (1988) Mammary angiosarcoma. The prognostic significance of the tumor differentiation. Cancer 62, 2145–2151.

    Article  PubMed  CAS  Google Scholar 

  32. Donnell RM, Rosen PP, Lieberman PH, et al. (1981) Angiosarcoma and other vascular tumors of the breast. Pathologic analysis as a guide to prognosis. Am. J. Surg. Pathol. 5, 629–642.

    Article  PubMed  CAS  Google Scholar 

  33. Wiseman C, Liao KT (1972) Primary lymphoma of the breast. Cancer 29, 1705–1712.

    Article  PubMed  CAS  Google Scholar 

  34. Mambo NC, Burke JS, Butler JJ (1977) Primary malignant lymphomas of the breast. Cancer 39, 2033–2040.

    Article  PubMed  CAS  Google Scholar 

  35. Dixon JM, Lumsden AB, Krajewski A, et al. (1987) Primary lymphoma of the breast. Br. J. Surg. 74, 214–217.

    Article  PubMed  CAS  Google Scholar 

  36. D’Orsi CJ, Feldbaus L, Sonnenfeld M (1983) Unusual lesions of the breast. Radiol. Clin. North Am. 21, 67–80.

    PubMed  Google Scholar 

  37. Bobrow LG, Richards MA, Happerfield LC, et al. (1993) Breast lymphomas: a clinicopathologic review. Hum. Pathol. 24, 274–278.

    Article  PubMed  CAS  Google Scholar 

  38. Brustein S, Kimmel M, Lieberman PH, et al. (1987) Malignant lymphoma of the breast: a study of 53 patients. Ann. Surg. 205, 144–149.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Helena Chang MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jane Kakkis MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery, Fox Chase Cancer Center, Philadelphia, PA, USA

    Michael H. Torosian MD

Rights and permissions

Reprints and permissions

Copyright information

© 2002 Springer Science+Business Media New York

About this chapter

Cite this chapter

Chang, H., Kakkis, J. (2002). Sarcoma and Lymphoma of the Breast. In: Torosian, M.H. (eds) Breast Cancer. Current Clinical Oncology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-161-9_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-59259-161-9_19

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-216-2

  • Online ISBN: 978-1-59259-161-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation