Breast Cancer pp 235-243 | Cite as

Breast Cancer During Pregnancy

  • Mary L. Gemignani
  • Jeanne A. Petrek
Part of the Current Clinical Oncology book series (CCO)


Ten to 20% of the 178,700 new cases of breast cancer occurring yearly (1998 estimates) are found in women of childbearing age (1). The issue of pregnancy-associated breast cancer is very important, particularly as more women delay childbearing for personal or professional reasons. The delay in childbearing to the 30s or 40s occurs concordantly with an increasing incidence of breast cancer in those ages. Pregnancy-associated breast cancer has been traditionally defined as the diagnosis of breast cancer made during pregnancy or within 1 year afterward. It is estimated to have an incidence of 0.2–3.8% (2) and is reported to occur in 1/10,000–1/3000 pregnancies (3,4).


Breast Cancer Breast Masse Therapeutic Abortion Special Clinical Situation Nonpregnant Patient 
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  1. 1.
    Landis SH, Murray T, Bolden S, Wingo PA (1990) Cancer statistics, 1999. CA Cancer J. Clin. 49, 8–31.CrossRefGoogle Scholar
  2. 2.
    Wallack MK, Wolf JA Jr, Bedwinek J, et al. (1983) Gestational carcinoma of the female breast. Curr. Probi. Cancer 7, 1–58.CrossRefGoogle Scholar
  3. 3.
    Saunders CM, Baum M (1993) Breast cancer and pregnancy: a review. J. R. Soc. Med. 86, 162–165.PubMedGoogle Scholar
  4. 4.
    Anderson JM (1979) Mammary cancers and pregnancy. BMJ 1, 1124–1127.PubMedCrossRefGoogle Scholar
  5. 5.
    Swinford AE, Adler DD, Garver KA (1998) Mammographic appearance of the breasts during pregnancy and lactation: false assumptions. Acad. Radiol. 5, 467–472.PubMedCrossRefGoogle Scholar
  6. 6.
    Liberman L, Giess CS, Dershaw DD, Deutch BM, Petrek JA (1994) Imaging of pregnancy-associated breast cancer. Radiology 191, 245–248.PubMedGoogle Scholar
  7. 7.
    Adzick NS, Harrison MR (1994) The unborn surgical patient. Curr. Probl. Surg. 31, 1–68.PubMedCrossRefGoogle Scholar
  8. 8.
    Mattison DR, Angtuaco T (1988) Magnetic resonance imaging in prenatal diagnosis. Clin. Obstet. Gynecol. 31, 353–389.PubMedCrossRefGoogle Scholar
  9. 9.
    Bottles K, Taylor RN (1985) Diagnosis of breast masses in pregnant and lactating women by aspiration cytology. Obstet. Gynecol. 66, 76S - 78S.PubMedGoogle Scholar
  10. 10.
    Gupta RK, McHutchinson AGR, Dowle CS, Simpson JS (1993) Fine-needle aspiration cytodiagnosis of breast masses in pregnant and lactating women and its impact on management. Diagn. Cytopathol. 9, 156–159.PubMedCrossRefGoogle Scholar
  11. 11.
    Novotny DB, Maygarden SJ, Shermer RW, Frable WJ (1991) Fine needle aspiration of benign and malignant breast masses associated with pregnancy. Acta Cytol. 35, 676–686.PubMedGoogle Scholar
  12. 12.
    Gupta RK (1997) The diagnostic impact of aspiration cytodiagnosis of breast masses in association with pregnancy and lactation with an emphasis on clinical decision making. Breast J. 3, 131–134.CrossRefGoogle Scholar
  13. 13.
    Schackmuth EM, Harlow CL, Norton LW (1993) Milk fistula: a complication after core biopsy. AJR 161, 961–962.PubMedCrossRefGoogle Scholar
  14. 14.
    Haagenson CD (1971) Carcinoma of the breast in pregnancy. In: Haagensen CD (ed.) Diseases of the Breast, 2nd ed. WB Saunders, Philadelphia, p. 74–86.Google Scholar
  15. 15.
    Zemlickis D, Lishner M, Degendorfer P, et al. (1992) Maternal and fetal outcome after breast cancer in pregnancy. Am. J. Obstet. Gynecol. 166, 781–787.PubMedCrossRefGoogle Scholar
  16. 16.
    Petrek JA, Dukoff R, Rogatko A (1991) Pregnancy-associated breast cancer. Cancer 67, 869–872.PubMedCrossRefGoogle Scholar
  17. 17.
    Mazze RI, Kallen B (1989) Reproductive outcome after anesthesia and operation during pregnancy: a registry study of 5405 cases. Am. J. Obstet. Gynecol. 161, 1178–1185.PubMedCrossRefGoogle Scholar
  18. 18.
    Miller R, Mulvihill S (1976) Small head size after atomic radiation. Teratology 14, 355–357.PubMedCrossRefGoogle Scholar
  19. 19.
    Kimler BF (1998) Prenatal irradiation: a major concern for the developing brain. Int. J. Radial. Biol. 73, 423–434.CrossRefGoogle Scholar
  20. 20.
    Doll R, Wakeford R (1997) Risk of childhood cancer from fetal irradiation. Br. J. Radiol. 70, 130–139.PubMedGoogle Scholar
  21. 21.
    National Council on Radiation Protection and Measurements (1971) Report #39: Basic Radiation Protection Criteria. NCRP, Washington, DC.Google Scholar
  22. 22.
    Kuerer HM, Cunningham JD, Bleiweiss IT, et al. (1998) Conservative surgery for breast carcinoma associated with pregnancy. Breast J. 4, 171–176.CrossRefGoogle Scholar
  23. 23.
    Doll DC, Ringenberg S, Yarbro JW (1989) Antineoplastic agents and pregnancy. Semin. Oncol. 16, 337–346.PubMedGoogle Scholar
  24. 24.
    Zemlickis D, Lishner M, Degendorfer P, et al. (1992) Fetal outcome after in utero exposure to cancer chemotherapy. Arch. Intern. Med. 152, 573–576.PubMedCrossRefGoogle Scholar
  25. 25.
    Glantz JC (1994) Reproductive toxicology of alkylating agents. Obstet. Gynecol. Surv. 49, 709–715.PubMedCrossRefGoogle Scholar
  26. 26.
    Turchi JJ, Villasis C (1988) Anthracyclines in the treatment of malignancy in pregnancy. Cancer 61, 435–440.PubMedCrossRefGoogle Scholar
  27. 27.
    Berry DL, Theriault RL, Holmes FA, et al. (1999) Management of breast cancer during pregnancy using a standard protocol. J. Clin. Oncol. 17, 855–861.PubMedGoogle Scholar
  28. 28.
    Buekers TE, Lallas TA (1998) Chemotherapy in pregnancy. Obstet. Gynecol. Clin. North. Am. 25, 323–329.PubMedCrossRefGoogle Scholar
  29. 29.
    Kilgore AR, Bloodgood JC Tumors and tumor-like lesions of the breast in association with pregnancy. Arch. Surg. 18, 2079–2098.Google Scholar
  30. 30.
    White TT (1954) Carcinoma of the breast and pregnancy. Ann. Surg. 139, 9–18.PubMedCrossRefGoogle Scholar
  31. 31.
    Haagensen CD, Stout AP (1943) Carcinoma of the breast: criteria of operability. Ann. Surg. 118, 859–870, 1032–1051.Google Scholar
  32. 32.
    Harrington SW (1937) Carcinoma of the breast: results of surgical treatment when the carcinoma occurred in course of pregnancy or lacation and when pregnancy occurred subsequent to operation, 1910–1933. Ann. Surg. 106, 690–700.PubMedCrossRefGoogle Scholar
  33. 33.
    Byrd BF, Bayer DS, Robertson JC, et al. (1962) Treatment of breast tumors associated with pregnancy and lactation. Ann. Surg. 155, 940–947.PubMedGoogle Scholar
  34. 34.
    Bunker ML, Peters MV (1963) Breast cancer associated with pregnancy or lactation. Am. J. Obstet. Gynecol. 85, 312–321.PubMedGoogle Scholar
  35. 35.
    Montgomery TL (1961) Detection and disposal of breast cancer in pregnancy. Am. J. Obstet. Gynecol. 81, 926–933.PubMedGoogle Scholar
  36. 36.
    Miller HK (1962) Cancer of the breast during pregnancy and lactation. Am. J. Obstet. Gynecol. 83, 607–611.PubMedGoogle Scholar
  37. 37.
    Peters VM, Meakin JW (1965) The influence of pregnancy in carcinoma of the breast. Prog. Clin. Cancer 1, 471–506.Google Scholar
  38. 38.
    Mickal A, Tones JE, Mule JG (1963) Carcinoma of breast in pregnancy and lactation. Am. Surg. 29, 509–514.PubMedGoogle Scholar
  39. 39.
    Rosemond GP (1963) Carcinoma of the breast during pregnancy. Clin. Obstet. Gynecol. 6, 994–1001.CrossRefGoogle Scholar
  40. 40.
    DeVitt JE, Beanie WG, Stoddart TG (1964) Carcinoma of the breast and pregnancy. Can. J. Surg. 7, 124–128.PubMedGoogle Scholar
  41. 41.
    Clark RM, Reid J (1978) Carcinoma of the breast in pregnancy and lactation. Int. J. Radias. Oncol. Biol. Phys. 4, 693–698.CrossRefGoogle Scholar
  42. 42.
    Applewhite RR, Smith LR, DeVicenti F (1973) Carcinoma of the breast associated with pregnancy and lactation. Am. Surg. 39, 101–104.PubMedGoogle Scholar
  43. 43.
    Crosby CH, Barclay THC (1971) Carcinoma of the breast: surgical management of patients with special conditions. Cancer 28, 1628–1636.PubMedCrossRefGoogle Scholar
  44. 44.
    Anderson BO, Petrek JA, Byrd DR, Senie RT, Borgen PI (1996) Pregnancy influences breast cancer stage at diagnosis in women 30 years of age and younger. Ann. Surg. Oncol. 3, 204–211.PubMedCrossRefGoogle Scholar
  45. 45.
    Nugent P, O’Connell TX (1985) Breast cancer and pregnancy. Arch. Surg. 120, 1221–1224.PubMedCrossRefGoogle Scholar
  46. 46.
    King RM, Welch JS, Martin JL, et al. (1985) Carcinoma of the breast associated with pregnancy. Surg. Gynecol. Obstet. 160, 228–232.PubMedGoogle Scholar
  47. 47.
    Ribeiro GG, Jones DA, Jones M (1986) Carcinoma of the breast associated with pregnancy. Br. J. Surg. 73, 607–609.PubMedCrossRefGoogle Scholar
  48. 48.
    Deemarsky LJ, Neishtadt EL (1980) Breast cancer and pregnancy. Breast 7, 17–21.Google Scholar
  49. 49.
    Tretli S, Kvalheim G, Thoresen S, Host H (1988) Survival of breast cancer patients diagnosed during pregnancy or lactation. Br. J. Cancer. 58, 382–384.PubMedCrossRefGoogle Scholar
  50. 50.
    Bonnier P, Romain S, Dilhuydy JM, et al. (1997) Influence of pregnancy on the outcome of breast cancer: a case-control study. Societé Française de Sénologie et de Pathologie Mammaire Study Group. Int. J. Cancer 72, 720–727.PubMedCrossRefGoogle Scholar
  51. 51.
    Ishida T, Yokoe T, Kasumi F, et al. (1992) Clinicopathologic characteristics and prognosis of breast cancer patients associated with pregnancy and lactation: analysis of case-control study in Japan. Jpn. J. Cancer Res. 83, 1143–1149.PubMedCrossRefGoogle Scholar
  52. 52.
    Lethaby AE, O’Neill MA, Mason BH, Holdaway IM, Harvey VJ (1996) Overall survival from breast cancer in women pregnant or lactating at or after diagnosis. Auckland Breast Cancer Study Group. Int. J. Cancer 67, 751–755.PubMedCrossRefGoogle Scholar
  53. 53.
    Ezzat A, Raja MA, Berry J, et al. (1996) Impact of pregnancy on non-metastatic breast cancer: a case control study. Clin. Oncol. 8, 367–370.CrossRefGoogle Scholar
  54. 54.
    Haagensen CD, Stout AP (1943) Carcinoma of the breast: criteria of operability. Ann. Surg. 118, 859–870.PubMedGoogle Scholar
  55. 55.
    Adair FE (1953) Cancer of the breast. Surg. Clin. North Am. 33, 313–319.Google Scholar
  56. 56.
    Holleb AI, Farrow JH (1962) The relation of carcinoma of the breast and pregnancy in 283 patients. Surg. Gynecol. Obstet. 115, 65–71.PubMedGoogle Scholar
  57. 57.
    Clark RIVI, Chua T (1989) Breast cancer and pregnancy: the ultimate challenge. Clin. Oncol. 1, 11–18.CrossRefGoogle Scholar

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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Mary L. Gemignani
  • Jeanne A. Petrek

There are no affiliations available

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