Breast Cancer pp 193-209 | Cite as

Oncogenes in the Development of Breast Cancer

  • Xiao Tan Qiao
  • Kenneth L. van Golen
  • Sofia D. Merajver
Part of the Current Clinical Oncology book series (CCO)


The diagnosis, treatment, and prevention of breast cancer are being influenced by recent advances in our understanding of the molecules implicated in tumor development and progression. The Human Genome Project will increase knowledge of the molecular determinants of breast cancer suddenly and drastically. The utilization of this knowledge in the clinic, however, will lag by a few years. It is thus important to consider the present state of knowledge of some of the key molecular markers that are presently used in the clinic to care for breast cancer patients and individuals at high risk for developing breast cancer. In this chapter, we summarize the main features of two oncogenes (bcl2 and HER-2/neu) and three tumor suppressor genes (BRCA1,BRCA2, and p53). For each of these genes and gene products, we review the present knowledge of their function, with special emphasis on those aspects that have led to or supported their translation to the clinic.


Breast Cancer Ovarian Cancer Epidermal Growth Factor Receptor BRCA2 Gene Human Breast Carcinoma 
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© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Xiao Tan Qiao
  • Kenneth L. van Golen
  • Sofia D. Merajver

There are no affiliations available

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