Abstract
The nucleosome is the repeating structural unit in the chromatin. It consists of the DNA and the protein part, the histones. The protein component is assembled by the core histones H2A, H2B, H3, and H4 (1).The amino-terminal ends of the histone proteins are subject to post-translational modifications, namely, acetylation, methylation (2), phosphorylation, and ADP-ribosylation. The reversible acetylation is an important regulator of chromatin higher-order structure and its interactions with nuclear non-histone proteins (3). The level of acetylation is maintained by histone acetyltransferases (HATS) and histone deacetylases (HDACs). This chapter reviews the literature concerning the impact of histone deacetylase on chromatin structure and gene activity especially in the context of the pathogenesis and potential treatment of cancer.
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Jung, M. (2002). Histone Deacetylases. In: La Thangue, N.B., Bandara, L.R. (eds) Targets for Cancer Chemotherapy. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-153-4_7
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