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Nuclear β-Catenin Signaling as a Target for Anticancer Drug Development

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Targets for Cancer Chemotherapy

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

β-Catenin is a multifunctional protein that acts as a component of the adherens junction regulating homotypic cell—cell adhesion and as a co-activator of the transcription of lymphoid enhancer binding factor/T cell-specific factor (LEF/ TCF) target genes (1–3). β-Catenin was first identified as a 92–94 kDa protein associated with the cytoplasmic tail of the E-cadherin adhesion protein (4, 5). At that time, two other members of the catenin family, α and γ catenin, were also isolated in association with E-cadherin (6). The name catenin is derived from the Latin catena or chain, because the catenins were thought to link E-cadherin and the cytoskeleton (7). This hypothesis was substantiated when it was shown that the ability of E-cadherin to function as a mediator of homotypic cell—cell interactions is dependent on catenins (8–11).

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Authors
  1. Eun Joo Chung
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  2. Paolo Bonvini
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  3. Ho Jung Oh
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  4. Len Neckers
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  5. Jane Trepel
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Editors and Affiliations

  1. Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland

    Nicholas B. La Thangue (Cathcart Professor of Biochemistry, Chief Scientific Officer) (Cathcart Professor of Biochemistry, Chief Scientific Officer)

  2. Prolifix Ltd., Abingdon, Oxon, UK

    Nicholas B. La Thangue (Cathcart Professor of Biochemistry, Chief Scientific Officer) (Cathcart Professor of Biochemistry, Chief Scientific Officer)

  3. Oxford Glycosciences Ltd., Abingdon, Oxon, UK

    Lasantha R. Bandara

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Chung, E.J., Bonvini, P., Oh, H.J., Neckers, L., Trepel, J. (2002). Nuclear β-Catenin Signaling as a Target for Anticancer Drug Development. In: La Thangue, N.B., Bandara, L.R. (eds) Targets for Cancer Chemotherapy. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-153-4_5

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  • DOI: https://doi.org/10.1007/978-1-59259-153-4_5

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-263-6

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