Abstract
About one in eleven women in the Western world develop cancer of the breast, and at least 5% of these cases are thought to result from a hereditary predisposition to the disease (1,2). Two breast cancer susceptibility (BRCA) + genes have been mapped and cloned, and mutations in these genes account for most families with four or more cases of breast cancer diagnosed before age 60. Women who inherit loss-of-function mutations in either of these genes have up to an 85% risk of breast cancer by age 70 (1). Both BRCA1 and BRCA2 are thought to be tumorsuppressor genes, as the wild-type allele of the gene is observed to be lost in tumors of heterozygous carriers. As well as breast cancer, carriers of mutations in these genes are at elevated risk of cancer of the ovary, prostate, and pancreas.
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Gabriel, A., Ashworth, A. (2002). The Breast Cancer Susceptibility Genes BRCA1 and BRCA2 . In: La Thangue, N.B., Bandara, L.R. (eds) Targets for Cancer Chemotherapy. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-153-4_11
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DOI: https://doi.org/10.1007/978-1-59259-153-4_11
Publisher Name: Humana Press, Totowa, NJ
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