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Handbook of Neurotoxicology pp 47–63Cite as

Agents Affecting Sodium Channels

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Abstract

Voltage sensitive sodium channels are widely recognized as the site of action for two classes of insecticides, the diphenylethanes (e.g., DDT and analogs) and the pyrethroids. Diphenylethane insecticides have not been used in significant quantity in the United States for more than two decades, but pyrethroids are one of the most important and widely used classes of insecticides. This chapter considers the actions of pyrethroids on voltage sensitive sodium channels and other putative sites of action and assesses the significance of those effects in determining the toxic actions of these compounds.

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  1. David M. Soderlund
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  1. The National Health and Environmental Effects Research Laboratory, Research Triangle Park, Durham, NC, USA

    Edward J. Massaro

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Soderlund, D.M. (2002). Agents Affecting Sodium Channels. In: Massaro, E.J. (eds) Handbook of Neurotoxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-132-9_4

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  • DOI: https://doi.org/10.1007/978-1-59259-132-9_4

  • Publisher Name: Humana Press, Totowa, NJ

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