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Molecular Mechanism of Action of Botulinal Neurotoxins and the Synaptic Remodeling They Induce In Vivo at the Skeletal Neuromuscular Junction

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Handbook of Neurotoxicology

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Abstract

Botulinal neurotoxins (BoNTs) have long been known to have potent and specific paralytic effects at the vertebrate neuromuscular junction (NMJ). Although they are the most toxic substances known, the serotype A is now being used for therapeutic purposes, mainly to treat involuntary muscle contractions, but also for a number of other medical applications (reviewed in ref. 1).

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Authors
  1. Frédéric A. Meunier
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  2. Judit Herreros
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  3. Giampietro Schiavo
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  4. Bernard Poulain
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  5. Jordi Molgó
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  1. The National Health and Environmental Effects Research Laboratory, Research Triangle Park, Durham, NC, USA

    Edward J. Massaro

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Meunier, F.A., Herreros, J., Schiavo, G., Poulain, B., Molgó, J. (2002). Molecular Mechanism of Action of Botulinal Neurotoxins and the Synaptic Remodeling They Induce In Vivo at the Skeletal Neuromuscular Junction. In: Massaro, E.J. (eds) Handbook of Neurotoxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-132-9_17

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  • DOI: https://doi.org/10.1007/978-1-59259-132-9_17

  • Publisher Name: Humana Press, Totowa, NJ

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