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Role of Chemokines and Their Receptors in the Induction and Regulation of Autoimmune Disease

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Cytokines and Autoimmune Diseases

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Abstract

Chemokines are a large superfamily of approximately 50 peptides. Although they are involved in diverse processes, their central and defining role in mammals appears to be action toward subpopulations of leukocytes (1). This specificity is mediated by selective expression of chemokine receptors, heptahelical G-protein coupled membrane molecules. With time and further study, chemokines have now been implicated in developmental organogenesis, angiogenesis, neoplasia, differentiation, and a host of other physiological and pathological processes (2, 3). Considerable interest has been sparked by the discovery that several chemokine receptors are essential invasion coreceptors for human immunodeficiency virus (HIV)-1 and HIV-2 infection of human cells (4, 5).

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Authors
  1. Richard M. Ransohoff
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  2. William J. Karpus
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Editors and Affiliations

  1. Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Vijay K. Kuchroo DVM, PhD , David A. Hafler MD  & Lindsay B. Nicholson PhD, MB ,  & 

  2. Department of Immunology, Scripps Research Institute, La Jolla, CA, USA

    Nora Sarvetnick PhD

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Ransohoff, R.M., Karpus, W.J. (2002). Role of Chemokines and Their Receptors in the Induction and Regulation of Autoimmune Disease. In: Kuchroo, V.K., Sarvetnick, N., Hafler, D.A., Nicholson, L.B. (eds) Cytokines and Autoimmune Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-129-9_7

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