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Transcriptional Regulation of Cytokine Gene Expression in Th Subsets

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Cytokines and Autoimmune Diseases

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Abstract

Cytokines are produced by a diverse array of cell types in response to antigenic stimulation and are instrumental in regulating the immune response. The expression of many key cytokines is controlled at the level of transcription. Because a considerable part of the experimental data pertaining to cytokine gene expression has been gathered in the context of studying the transcriptional regulation of CD4+ T helper cells as they differentiate into cytokine-producing effector cells, this will serve as both an illustrative model and the focus of this chapter.

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Authors
  1. Jyothi Rengarajan
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  2. Laurie H. Glimcher
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Editors and Affiliations

  1. Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Vijay K. Kuchroo DVM, PhD , David A. Hafler MD  & Lindsay B. Nicholson PhD, MB ,  & 

  2. Department of Immunology, Scripps Research Institute, La Jolla, CA, USA

    Nora Sarvetnick PhD

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Rengarajan, J., Glimcher, L.H. (2002). Transcriptional Regulation of Cytokine Gene Expression in Th Subsets. In: Kuchroo, V.K., Sarvetnick, N., Hafler, D.A., Nicholson, L.B. (eds) Cytokines and Autoimmune Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-129-9_1

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  • DOI: https://doi.org/10.1007/978-1-59259-129-9_1

  • Publisher Name: Humana Press, Totowa, NJ

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