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Antimalarial Chemotherapy pp 43–63Cite as

The Plasmodium Food Vacuole

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Part of the book series: Infectious Disease ((ID))

Abstract

The Plasmodium food vacuole is a sophisticated organelle optimized for hemoglobin metabolism. It is the site of acidification, hemoglobin proteolysis, peptide transport, heme polymerization, detoxification of oxygen radicals, and quinoline action. A number of proteins that function in the food vacuole are known. Among them are aspartic, cysteine, and metalloproteases, an ATP-binding cassette (ABC) transporter, an ATPase, a heme polymerase, and several oxidant defense enzymes. In this chapter, we review the molecular details of food vacuole function and highlight potential targets for antimalarial drug development.

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Authors
  1. Ritu Banerjee
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  2. Daniel E. Goldberg
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  1. School of Medicine, University of California, San Francisco, CA, USA

    Philip J. Rosenthal MD

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Banerjee, R., Goldberg, D.E. (2001). The Plasmodium Food Vacuole. In: Rosenthal, P.J. (eds) Antimalarial Chemotherapy. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-111-4_4

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  • DOI: https://doi.org/10.1007/978-1-59259-111-4_4

  • Publisher Name: Humana Press, Totowa, NJ

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