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Antimalarial Chemotherapy pp 255–263Cite as

New Antimalarial Trioxanes and Endoperoxides

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Part of the book series: Infectious Disease ((ID))

Abstract

Folk medicine is often a rich source of leads for discovery of valuable new drugs (1). Quinine was discovered this way, based on traditional medicinal use of the bark of the Cinchona tree, and the powerful anticancer drug taxol was discovered in Yew trees. Chinese folk medicine has now led to isolation, identification, and clinical use of artemisinin (qinghaosu, 1) (Scheme I), a sesquiterpene 1,2,4-trioxane lactone, for rapid and effective chemotherapy of individuals infected with Plasmodium falciparum malaria parasites (2).

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Authors
  1. Gary H. Posner
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  2. Mikhail Krasavin
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  3. Michael McCutchen
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  4. Poonsakdi Ploypradith
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  5. John P. Maxwell
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  6. Jeffrey S. Elias
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  7. Michael H. Parker
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Editor information

Editors and Affiliations

  1. School of Medicine, University of California, San Francisco, CA, USA

    Philip J. Rosenthal MD

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© 2001 Springer Science+Business Media New York

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Posner, G.H. et al. (2001). New Antimalarial Trioxanes and Endoperoxides. In: Rosenthal, P.J. (eds) Antimalarial Chemotherapy. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-111-4_14

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  • DOI: https://doi.org/10.1007/978-1-59259-111-4_14

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-124-0

  • Online ISBN: 978-1-59259-111-4

  • eBook Packages: Springer Book Archive

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