Immune Response to HTLV-I and HTLV-II

  • Samantha S. Soldan
  • Steven Jacobson
Part of the Infectious Disease book series (ID)


Originally identified from a T-lymphoblastoid cell line (HUT 102) of a patient diagnosed with a cutaneous T-cell lymphoma, the human T-lymphotropic virus type I (HTLV-I) was the first described human retrovirus (1). In 1981, HTLV-I was established as the etiologic agent for adult T-cell leukemia (ATL) (2), a hematological malignancy first characterized in Japan (3). Since the initial description of ATL and the discovery of HTLV-I, the virus has been associated with an inflammatory, chronic, progressive neurologic disease known as HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) in addition to several other inflammatory diseases (4–14). Although an increasing number of human diseases have been linked to HTLV-I the vast majority of HTLV-I—infected individuals remain clinically asymptomatic.


Proviral Load Spastic Paraparesis Tropical Spastic Paraparesis Cell Leukemia Virus Type Photropic Virus Type 
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Copyright information

© Humana Press Inc., Totowa, NJ 2001

Authors and Affiliations

  • Samantha S. Soldan
  • Steven Jacobson

There are no affiliations available

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