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Role of Fibroblast Growth Factor-2 in Astrogliosis

  • Chapter
Neuroglia in the Aging Brain

Part of the book series: Contemporary Neuroscience ((CNEURO))

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Abstract

Astrocytes comprise the most numerous cellular element of the brain. Though once thought to merely provide structural support for neurons, astrocytes are now known to participate in many aspects of normal nervous system development and function, including neuronal migration, synaptogenesis, induction of the blood-brain-barrier, metabolic support of neurons, and regulation of extracellular fluid composition. Astrocytes throughout the brain are electrically coupled, forming a glial syncytium that may play a substantial role in signaling within the nervous system (1). In addition to functions in the developing and adult nervous systems, astrocytes respond to changes in the brain caused by aging and injury.

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  1. UCLA Mental Retardation Research Center, Los Angeles, CA, USA

    Jean S. de Vellis PhD

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Reilly, J.F. (2002). Role of Fibroblast Growth Factor-2 in Astrogliosis. In: de Vellis, J.S. (eds) Neuroglia in the Aging Brain. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-105-3_10

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  • DOI: https://doi.org/10.1007/978-1-59259-105-3_10

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