Abstract
Dyspepsia is defined as pain or discomfort centered in the upper abdomen (1). Pain in the central portion of the abdomen is essential for the diagnosis and pain located in other areas is excluded. Discomfort is a subjective negative feeling that may not be interpreted by the patient as pain, and may include a variety of symptoms, including fullness in the upper abdomen, early satiety, bloating, or nausea. The definition of dyspepsia includes patients who have intermittent or continuous symptoms, and does not specify the duration of symptoms. Thus, dyspepsia may be of short or long duration.
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References
Talley NJ, Stanghellii V, Heading RC, et al. (1999) Functional gastroduodenal disorders. Gut 45: 1137–1142.
Tally NJ, McNeil D, Hayden A,C et al. (1987) Prognosis of chronic unexplained dyspepsia. Gastroenterology 92: 1060–1066.
Tally NJ, Zinsmeister AR, Schleck CD, Melton LJ III. (1992) Dyspepsia and dyspepsia subgroups: a population based study. Gastroenterology 102: 1259–1268.
Stanghellini V. (1999) Three-month prevalence rates of gastrointestinal symptoms and the influence of demographic factors: results from the domestic/international gastroenterology surveillance study (DIGEST). Scand J Gastroenterol 34: 231: 20–28.
Bytzer P, Moller Hansen J, Schaffalizky de Muckadell GB, Malchow-Moller A. (1997) Predicting endoscopic diagnosis in the dyspeptic patient. Scand J Gastroenterol 32: 118–125.
Klauser AG, Schindlbeck NE, Muller-Lissner SA. (1990) Symptoms in gastroesophageal reflux disease. Lancet 335: 205–208.
Stanghellini V, Tosetti C, Paternico A, et al. (1999) Predominant symptoms identify different subgroups in functional dyspepsia. Am J Gastroenterol 94: 2080–2085.
Meineche-Schmidt V, Talley NJ, Pap A, et al. (1999) Impact of functional dyspepsia on quality of life and health care consumption after cessation of anti-secretory treatment. Scand J Gastroenterol 34: 566–574.
Enck P, Dubois D, Marquis P. (1999) Quality of life in patients with upper gastrointestinal symptoms: results from the Domestic/International Gastroenterology Surveillance Study (DIGEST). Scand J Gastroenterol 34 (Suppl 231): 48–54.
Kagevi I, Lofstedt S, Persson L-G. (1989) Endoscopic findings and diagnoses in unselected dyspeptic patients at a primary health care center. Scand J Gastroenterol 24: 145–150.
Gear MWL, Barnes RJ. (1980) Endoscopic studies of dyspepsia in general practice. Br Med. J 1: 1136–1137.
Health and Policy Committee. American College of Physicians. (1985) Endoscopy in the evaluation of dyspepsia. Ann Intern Med 102: 266–269.
Bytzer P, Hansen J, de Muckadell O. (1994) Empirical H2 blocker therapy or prompt endoscopy in management of dyspepsia. Lancet 343: 811–815.
Silverstein M, Petterson T, Talley NJ. (1996) Initial endoscopy or empirical therapy with or without testing for H. pylori for dyspepsia: a decision analysis. Gastroenterology 110: 72–83.
The European H pylori Study Group. (1997) Current European concepts on the management of Helicobacter pylori infection. The Maastricht Consensus report. Gut 41: 8–13.
Rubin G, Meineche-Schmidt V, Roberts A, et al. (1999) Management of Helicobacter pylori infection in primary care. Guidelines from the ESPCG. Eur J Clin Pract 5: 98–104.
American Gastroenterological Association Medical Position Statement (1998) Evaluation of dyspepsia. Gastroenterology 114: 579–581.
Howden C, Hunt R. (1998) Guidelines for the management of Helicobacter pylori infection. Am J Gastroenterol 93: 2330–2338.
Patel P, Khulusi S, Mendall MA, et al. (1995) Prospective screening of dyspeptic patients by Helicobacter pylori serology. Lancet 346: 1315–1316.
Asante M, Mendall M, Patel P. (1998) Randomized trial of endoscopy vs. no endoscopy in the management of seronegative Helicobacter dyspepsia. Eur J Gastroenterol Hepatol 10: 983–989.
Wiklund I, Glise H, Jerndal P, Carlsson J, Talley NJ. (1998) Does endoscopy have a positive impact on the quality of life in dyspepsia? Am J Gastroenterol 47: 449–454.
Vaira D, Stanghellini V, Menegatti M, et al. (1997) Italian Helicobacter pylori Study Group. Endoscopy 29: 595–601.
Lassen AT, Pederson FM, Bytzer P, de Muckadel Schaffalitzky OB. (1998) H. pylori test and treat or prompt endoscopy for dyspeptic patients in primary care. A randomized controlled trial of 2 management strategies: one year follow-up. Gastroenterology 114:A196(Abstract).
Heaney A, Collins JSA, Watson RGP, et al. (1999) Prospective randomized trial of a “test and treat” policy versus endoscopy based management in young Helicobacter pylori positive patients with ulcer-like dyspepsia referred to a hospital clinic. Gut 45: 186–190.
Jones R, Taitr C, Sladen G, Weston-Baker J. (1999) Trial of a test and treat strategy for Helicobacter pylori positive dyspeptic patients in general practice. Int J Clin Pract 53: 413–416.
Ladabaum U, Fendrick AM, Schieman JM. (1998) Utilization and outcomes of office-based testing for Helicobacter pylori (HP) in symptomatic primary care patients. Gastroenterology 114: A24.
Duggan A, Elliot C, Tolly K, et al. (2000) Randomized controlled trial of four dyspeptic management strategies in primary care with 12 months follow-up. Gastroenterology 118: A438 (Abstract).
Farkk M, Sarna S, Valtonen V, Sipponen P. (2000) “Test and treat” strategy for management of uninvestigated dyspepsia in primary care. Gastroenterology 118:A438(Abstract).
Chiba N, Veldhuyzen van Zanten S, Sinclair P, et al. (2000) Beneficial effect of H. plori eradication therapy on long-term symptom relief in primary care patients with uninvestigated dyspepsia: the Cadet-Hp study. Gastroenterology 118: A438 (Abstract).
Schilling D, Ott M, Messerer P, et al. (2000) Cure of Helicobacter pylori infection in uninvestigated dyspepsia: a 12 month follow-up study from a health initiative in a large company. Gastroenterology 118: A439 (Abstract).
Allison J, Levin T, Ackerson L, et al. (2000) Test and treat for H. pylori clinical outcomes in an HMO population on chronic acid suppersion therapy for physician diagnosed peptic ulcer disease. Gastroenterology 118: A438 (Abstract).
Breslin N, Thomson A, Bailey R, Blustein P. (2000) Gastric cancer with other endoscopic diagnoses in patients with benign dyspepsia. Gut 46: 93–97.
Blum AL, Talley NJ, Morain C, et al. (1998) Lack of effect of treating Helicobacter pylori infection in patients with nonulcer dyspepsia. New Engl J Med 339: 1869–1874.
Talley NJ, Jenssens J, Lauritsen K, et al. (1999) Eradication of Helicobacter pylori in functional dyspepsia-randomized double blind placebo controlled trial with 12 months follow-up. Br Med J 318: 833–837.
Talley NJ, Vakil N, Ballard ED, Fennerty B. (1999) Absence of benefit of eradicating Helicobacter pylori in patients with nonulcer dyspepsia. New Engl J Med 341: 1106–1111.
McColl K, Murray L, El-Omar E, et al. (1998) Symptomatic benefit from eradicating H. pylori in patients with nonulcer dyspepsia. New Engl JMed 1339: 1869–1874.
McColl K, El-Nujumi A, Murray N, et al. (1997) Helicobacter pylori breath test: a surrogate marker for peptic ulcer disease in dyspeptic patients. Gut 40: 302–306.
Laine L, Schoenfeld P, Fennerty B. (2000) H. pylori therapy is not effective for treatment of non-ulcer dyspepsia: meta-analysis of randomized controlled trials. Gastroenterology 118: A440 (Abstract).
Greenberg P, Cello J. (1999) Lack of effect of treatment for Helicobacter pylori on symptoms of nonulcer dyspepsia. Arch Int Med 159: 2283–2288.
Talley N, Meineche-Achmidt V, Pare P, et al. (1998) Effect of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies). Aliment Pharmacol Ther 12: 1055–1065.
Peura D, Kovacs T, Metz D, Gudmundson J, Pilmer B. (2000) Low-dose Lansoprazole: effective for non-ulcer dyspepsia (NUD). Gastroenterology A439 (Abstract).
Farup P, Hovde O, Torp R, Wetterhus S. (1999) Patients with functional dyspepsia responding to omeprazole have a characteristic gastro-esophageal reflux pattern. Scand J Gastroenterol 34: 575–579.
Finney JS, Kinnersley N, Hughes M, et al. (1998) Meta-analysis of anti-secretory and gastrokinetic compounds in functional dyspepsia. J Clin Gastroenterol 26: 312–320.
Tack J, Pissevaux H, Coulie B, et al. (1998) Role of impaired gastric accommodation to a meal in functional dyspepsia. Gastroenterology 115: 1346–1352.
Zerbib F, ruley des Varannes S, Oriola R, et al. (1994) Alosetron does not affect the visceral perception of gastric distention in healthy subjects. Aliment Pharmacol Ther 18: 403–407.
Klatt S, Bock W, Rentschler J, et al. (1999) Effects of Tropisetron, a 5-HT3 receptor antagonist on proximal gastric motor and sensory function in non-ulcer dyspepsia. Digestion 60: 147–152.
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Vakil, N. (2001). Dyspepsia and Nonulcer Dyspepsia. In: Freston, J.W. (eds) Diseases of the Gastroesophageal Mucosa. Clinical Gastroenterology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-103-9_7
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DOI: https://doi.org/10.1007/978-1-59259-103-9_7
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