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Use of Transgenic Animals in Skeleton Biology

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Transgenics in Endocrinology

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

Three areas of skeletal biology that have benefited from the achievements in mouse genetics are skeletal patterning, cell differentiation and physiology. Skeleton patterning, or the position, type, length and shape of each individual skeletal element, is genetically controlled. Many of the genes involved have been implicated from their mutations, as identified through human genetics. However, it is only during recent mouse studies, knockout, misexpression, and overexpression that the actual function of these genes has been confirmed. In addition, a number of genes that act downstream have been identified. In terms of cell differentiation, transcription factors specific for differentiation of osteoblasts, osteoclasts, and chondrocytes (cells of the skeleton) were determined in the last decade, and it is highly probable that the identified genes represent only a small portion of the total genes involved. Finally, mouse genetics has provided clues about the function of structural proteins of the bone matrix that other biological assays could not provide.

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Authors
  1. Thomas Günther PhD
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  2. Mary Jo Doherty PhD
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  3. Gerard Karsenty MD, PhD
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Editor information

Editors and Affiliations

  1. Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

    Martin M. Matzuk MD, PhD

  2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

    Chester W. Brown MD, PhD

  3. Departments of Pathology, and Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA

    T. Rajendra Kumar PhD

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© 2001 Humana Press Inc., Totowa, NJ

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Günther, T., Doherty, M.J., Karsenty, G. (2001). Use of Transgenic Animals in Skeleton Biology. In: Matzuk, M.M., Brown, C.W., Kumar, T.R. (eds) Transgenics in Endocrinology. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-102-2_18

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  • DOI: https://doi.org/10.1007/978-1-59259-102-2_18

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9640-6

  • Online ISBN: 978-1-59259-102-2

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