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Interleukin (IL)-1 Family of Cytokines and Corticotropin-Releasing Hormone (CRH) in the Adrenal Gland

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Adrenal Disorders

Part of the book series: Contemporary Endocrinology ((COE))

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Abstract

It is now well-established that the interleukin (IL)-1 family of cytokines initiates the acute immune response and, at the same time and in order to adapt the organism to the stress of inflammation, activates the two stress axes, i.e., the hypothalamuspituitary-adrenal (HPA) and the sympathetic. The initiation of the stress response by the IL-1 cytokines takes place centrally, at the central nervous system. There, the IL-1 cytokines stimulate the production of corticotropin-releasing hormone (CRH) in the parvocellular part of the paraventricular hypothalamic nucleus and the production of norepinephrine in hypothalamus and locus ceruleus.

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  1. Andrew N. Margioris
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  2. Erene Dermitzaki
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  3. Maria Venihaki
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  4. Achille Gravanis
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Editors and Affiliations

  1. Department of Clinical Chemistry, University of Crete School of Medicine, Heraklion, Crete, Greece

    Andrew N. Margioris MD

  2. Pediatric and Reproductive Endocrinology Branch, National Institute of Child and Human Development, National Institute of Health, Bethesda, MD, USA

    George P. Chrousos MD

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Margioris, A.N., Dermitzaki, E., Venihaki, M., Gravanis, A. (2001). Interleukin (IL)-1 Family of Cytokines and Corticotropin-Releasing Hormone (CRH) in the Adrenal Gland. In: Margioris, A.N., Chrousos, G.P. (eds) Adrenal Disorders. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-101-5_9

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  • DOI: https://doi.org/10.1007/978-1-59259-101-5_9

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