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Human Tumor Xenografts and Explants

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Tumor Models in Cancer Research

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Since the first report of the successful xenografting of a human tumor into nude mice in 1969, there have been numerous studies conducted throughout the world using the nude mouse as a tool to answer a variety of questions regarding the cause, prevention, and therapy of cancer. Thus, the role of immunodeficient animals in oncology has continuously increased, and the athymic nude mouse has proven to be an outstanding host for many human solid-tumor xenografts (1,2). These mice are now extensively used in the development of potential anticancer drugs, new antineoplastic treatment modalities, and studies of tumor biology (3–7). Moreover, mice with severe combined immunodeficiency (SCID) have enlarged the spectrum of possible applications in cancer research and enabled engraftments of human tumors that were previously difficult to explant, such as those of the hematopoietic system (8).

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Authors
  1. Heinz-Herbert Fiebig MD, PhD
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  2. Angelika M. Burger PhD
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Editor information

Editors and Affiliations

  1. Lilly Research Laboratories, Indianapolis, IN, USA

    Beverly A. Teicher

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© 2002 Springer Science+Business Media New York

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Fiebig, HH., Burger, A.M. (2002). Human Tumor Xenografts and Explants. In: Teicher, B.A. (eds) Tumor Models in Cancer Research. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-100-8_7

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  • DOI: https://doi.org/10.1007/978-1-59259-100-8_7

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-6883-1

  • Online ISBN: 978-1-59259-100-8

  • eBook Packages: Springer Book Archive

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