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Tissue-Isolated Tumors in Mice

Ex Vivo Perfusion of Human Tumor Xenografts

  • Chapter
Tumor Models in Cancer Research

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

The microenvironment surrounding cancer cells in vivo in a solid tumor exerts a profound influence on the tumor’s growth and response to treatment. The heterogeneous blood flow and the complex exchange between vascular, interstitial, and cellular compartments govern the nutrient delivery, the metabolic activity, and the transport of agents in the neoplastic tissue. In vivo studies of whole tumors do not separate the relative contributions from various blood-borne metabolites, and in vitro studies are far from representative of tissue conditions in a solid tumor in vivo. The ex vivo perfused preparation represents a useful link between extremes. This chapter discusses these tumor-model types and demonstrates the type of information that can be obtained by such models.

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Authors
  1. Paul E. G. Kristjansen MD, PhD
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Editors and Affiliations

  1. Lilly Research Laboratories, Indianapolis, IN, USA

    Beverly A. Teicher

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© 2002 Springer Science+Business Media New York

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Kristjansen, P.E.G. (2002). Tissue-Isolated Tumors in Mice. In: Teicher, B.A. (eds) Tumor Models in Cancer Research. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-100-8_23

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  • DOI: https://doi.org/10.1007/978-1-59259-100-8_23

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-6883-1

  • Online ISBN: 978-1-59259-100-8

  • eBook Packages: Springer Book Archive

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