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Anesthetic Considerations for the Study of Murine Tumor Models

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Tumor Models in Cancer Research

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

The choice and validation of anesthesia are important considerations in the study of whole-animal tumor models. Anesthesia is often necessary for humane restraint, and is absolutely required for invasive or noxious procedures. Ideally, anesthesia itself should exert little or no effect on normal tissue or tumor homeostasis. However, just as there are no “safe” anesthetic agents or procedures, there is no “ideal” or “best” anesthetic choice for the study of tumors in rats and mice. Anesthetic suitability for any given study is largely determined by the knowledge and skill of the user.

“There are no safe anesthetic agents; there are no safe anesthetic procedures; there are only safe anesthetists” — Robert Smith

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  1. Robert E. Meyer DVM
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  2. Rod D. Braun PhD
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  3. Mark W. Dewhirst DVM, PhD
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  1. Lilly Research Laboratories, Indianapolis, IN, USA

    Beverly A. Teicher

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Meyer, R.E., Braun, R.D., Dewhirst, M.W. (2002). Anesthetic Considerations for the Study of Murine Tumor Models. In: Teicher, B.A. (eds) Tumor Models in Cancer Research. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-100-8_22

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