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Murine Models of Bone-Marrow Transplant Conditioning

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Tumor Models in Cancer Research

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

Hematopoietic stem-cell transplantation (SCT) is a rapidly evolving clinical strategy for treating a variety of malignancies or disorders of the lymphohematopoietic system. Bone-marrow cells or, more recently, mobilized peripheral blood (MPB) stem cells, are used as a vital source of hematopoietic cells that can reconstitute the host and rescue the patient from an otherwise fatal bone-marrow aplasia induced by intensive cancer therapy. SCT is also envisaged as an essential prerequisite toward the induction of immunological tolerance in organ transplantation, and as a vehicle for gene therapy in the correction of a number of genetic diseases.

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Authors
  1. Ronald van Os PhD
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  1. Lilly Research Laboratories, Indianapolis, IN, USA

    Beverly A. Teicher

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van Os, R., Down, J.D. (2002). Murine Models of Bone-Marrow Transplant Conditioning. In: Teicher, B.A. (eds) Tumor Models in Cancer Research. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-100-8_21

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