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Metastasis Models

Lungs, Spleen/Liver, Bone, and Brain

  • Chapter
Tumor Models in Cancer Research

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

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Abstract

The metastatic spread of solid tumors is directly or indirectly responsible for most cancer-related deaths (1). Approximately 30% of cancer patients have clinically detectable metastases at the time of initial diagnosis, and 30–40% harbor occult metastases (2). There is an urgent clinical need to predict the metastatic potential of individual tumors, to identify occult metastatic foci, to prevent metastatic dissemination, and to prevent the transformation of tumors to more invasive phenotypes. Appropriate preclinical models can help to achieve these goals.

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Authors
  1. Krishna Menon MS
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  2. Beverly A. Teicher PhD
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  1. Lilly Research Laboratories, Indianapolis, IN, USA

    Beverly A. Teicher

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Menon, K., Teicher, B.A. (2002). Metastasis Models. In: Teicher, B.A. (eds) Tumor Models in Cancer Research. Cancer Drug Discovery and Development. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-100-8_16

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  • DOI: https://doi.org/10.1007/978-1-59259-100-8_16

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