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Conservation of Eukaryotic DNA Repair Mechanisms

  • Chapter
DNA Damage and Repair

Part of the book series: Contemporary Cancer Research ((CCR))

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Abstract

The fundamental importance of DNA repair for all organisms has become widely acknowledged in recent years. Evidence for the crucial role of DNA repair for the survival of all organisms comes from (1) the diversity of different repair processes; (2) the remarkable finding that about 2% of the Escherichia coli chromosome encodes proteins involved in DNA repair processes; (3) the extraordinary degree of evolutionary conservation of DNA repair mechanisms and proteins in all organisms. DNA repair pathways have been largely conserved from bacteria to mammals. In the vast majority of cases, the proteins that carry out these repair processes are conserved in structure and function in eukaryotes, and in some cases in bacteria as well. This conservation has been of great value in assisting our understanding of the mechanisms of DNA repair. The different strengths of working with yeasts on the one hand, which are very amenable to genetic analysis, and human cells on the other hand, which are often more amenable to biochemistry and provide relationships to human diseases, has greatly accelerated work in this area. Conclusions derived from the genetic and biochemical analysis of repair pathways in yeast can be extrapolated to human systems, and vice versa.

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Authors
  1. Alan R. Lehmann
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  2. Elaine M. Taylor
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Editors and Affiliations

  1. Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM, USA

    Jac A. Nickoloff

  2. Qbiogene, Carlsbad, CA, USA

    Merl F. Hoekstra

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© 2001 Humana Press Inc., Totowa, NJ

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Lehmann, A.R., Taylor, E.M. (2001). Conservation of Eukaryotic DNA Repair Mechanisms. In: Nickoloff, J.A., Hoekstra, M.F. (eds) DNA Damage and Repair. Contemporary Cancer Research. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-095-7_15

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  • DOI: https://doi.org/10.1007/978-1-59259-095-7_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9635-2

  • Online ISBN: 978-1-59259-095-7

  • eBook Packages: Springer Book Archive

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