Diabetes and Advanced Glycation End Products

  • Helen Vlassara
Part of the Contemporary Cardiology book series (CONCARD)


Prolonged exposure to hyperglycemia is now recognized as the primary causal factor in the majority of diabetic complications (1,2). Indeed, glucose has a wide range of effects on normal cell function that are reversible and reflect the transient nature of hyperglycemia (3,4). Significantly, many of the effects of hyperglycemia are irreversible and can cause progressive, cumulative cell dysfunction (5). This suggests that persistent rather than transient, acute metabolic changes are of pivotal importance in diabetic complications. Among the irreversible changes that occur as a direct result of hyperglycemia is the formation of advanced glycation end products (AGE), which have a range of chemical, cellular, and tissue effects and act as mediators, not only of diabetic complications but also of widespread changes associated with aging.


Diabetic Nephropathy Advanced Glycation Endproducts Nonenzymatic Glycosylation 
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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Helen Vlassara

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