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The Metabolic Syndrome and Vascular Disease

  • Aresh J. Anwar
  • Anthony H. Barnett
  • Sudhesh Kumar
Part of the Contemporary Cardiology book series (CONCARD)

Abstract

The concept of the metabolic syndrome is perhaps the most significant development in the management of cardiovascular disease in the last 10 years. Previously, physicians had often treated coexisting diabetes, hypertension, or dyslipidemia as separate diseases, without considering the impact of treatment for one on the other. Avogaro and Creapaldi (1) first described the syndrome over 40 years ago. The importance of the concept for everyday clinical practice was only highlighted in 1988, however, when Gerald Reaven (2) drew attention to a constellation of features associated with coronary heart disease (Table 1). In view of the rather limited understanding of the nature of the association of these features at that time, Reaven used the term syndrome X (3). He also suggested that insulin resistance played a central etiologic role in providing a link between these components.

Keywords

Insulin Resistance Coronary Heart Disease Metabolic Syndrome Coronary Heart Disease Mortality United Kingdom Prospective Diabetes Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2001

Authors and Affiliations

  • Aresh J. Anwar
  • Anthony H. Barnett
  • Sudhesh Kumar

There are no affiliations available

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