Abstract
Diabetes mellitus is a leading cause of morbidity and mortality mostly because of its vascular complications (1,2). Diabetic complications can be broadly classified into microvascular (retinopathy, nephropathy) and macrovascular (coronary artery disease [CAD], cerebrovascular disease, peripheral vascular disease). This chapter focuses on the role of oxidative stress in the genesis of diabetic macrovascular disease.
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References
Pyorala K, Laasko M, Uusitupa M. Diabetes and atherosclerosis: an epidemiologic view. Diabetes Metab Rev 1987; 3: 463–524.
Everhart JE, Pettitt DJ, Knowler WC, et al. Medial arterial calcification and its association with mortality and complications of diabetes. Diabetologia 1988; 31: 16–23.
Bierman E. Atherogenesis in diabetes. Arterioscl Thromb 1992; 12: 647–656.
Banga JD, Sixma JJ. Diabetes mellitus, vascular disease and thrombosis. Clin Hematol 1986; 15: 465–492.
Jones RL, Peterson CM. Hematologic alterations in diabetes mellitus. Am J Med 1981; 70: 339–352.
Brunzell JD, Chait A, Bierman EL. Plasma lipoproteins in human diabetes mellitus. In: The Diabetes Annual, Vol 1. Albertini KG, eds. Amsterdam: Elsevier, 1985; 463–479.
Howard BV. Lipoprotein metabolism in diabetes mellitus. J Lipid Res 1987; 28: 613–628.
Barakat HA, Carpenter JW, McLendon VD, et al. Influence of obesity, IGT and NIDDM on LDL structure and composition: possible link between hyperinsulinemia and atherosclerosis. Diabetes 1990; 39: 1527–1533.
Hulley SB, Rosenman RH, Bawol RD, Brand RJ. Epidemiology as a guide to clinical decisions: association between TG and CHD. N Engl J Med 1980; 302: 1383–1389.
Pietri AO, Dunn FL, Grundy SM, Raskin P. The effect of continuous subcutaneous insulin infusion on VLDL TG metabolism in Type 1 diabetes mellitus. Diabetes 1983; 32: 75–81.
Taskinen MR, Kuusi T, Helve E, et al. Insulin therapy induces anti-atherogenic changes of serum lipoproteins in NIDDM. Arteriosclerosis 1988; 8: 168–177.
Lyons TJ. Oxidized low density lipoproteins: a role in the pathogenesis of atherosclerosis in diabetes? Diabetic Med 1991; 8: 411–419.
Chait A, Brazg R, Tribble D, Krauss R. Susceptibility of small, dense LDL to oxidative modification in subjects with pattern B. Am J Med 1993; 94: 350–356.
Laasko M, Pyorala K, Sarlund H, Voutilainen E. Lipid and lipoprotein abnormalities associated with CAD in patients with IDDM. Arteriosclerosis 1986; 6: 679–684.
Gordon T, Castelli WP, Hjortland MC, et al. Diabetes, blood lipids and role of obesity in CAD risk for women: The Framingham Study. Ann Intern Med 1977; 87: 393–397.
Reaven G. Role of insulin resistance in human disease (syndrome X): an expanded definition. Annu Rev Med 1993; 44: 121–131.
DeFronzo R, Ferrannini E. Insulin resistance. A Multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173–194.
Lyons TJ, Jenkins Ai. Lipoprotein glycation and its metabolic consequences. Curr Opin Lipidol 1997; 8: 174–180.
Brownlee M. Glycation products and the pathogenesis of diabetic complications. Diabetes Care 1992; 15: 1835–1843.
Bucala R, Tracey K, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest 1991; 87: 432–438.
Bucala R, Cerami, A. Advanced glycosylation: chemistry, biology, and implications for diabetes and aging. Adv Pharmacol 1992; 23: 1–34.
Bucala R, Makita Z, Koschinski T, Cerami A, Vlassara H. Lipid advanced glycosylation: pathway for lipid oxidation in vivo. Proc Natl Acad Sci USA 1993; 90: 6434–6438.
Lopes-Virella M, Klein R, Lyons T, Stevenson H, Witztum J. Glycosylation of low-density lipoprotein enhances cholesteryl ester synthesis in human monocyte-derived macrophages. Diabetes 1988; 37: 550–557.
Brownlee M, Vlassara H, Kooney A, Ulrich P, Cerami A. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science 1986; 232: 1629–1632.
Witztum JL, Steinberg D. Role of Ox-LDL in atherogenesis. J Clin Invest 1991; 88: 1785–1792.
Berliner JA, Heinecke JW. The role of oxidized lipoproteins in atherogenesis. Free Rad Biol Med 1992; 92: 127–143.
Devaraj S, halal I. Oxidized LDL and atherosclerosis. Int J Clin Lab Res 1996, 26: 178–184.
Strain J. Disturbances of micronutrient and antioxidant status in diabetes. Proc Nutr Soc 1991; 50: 591–604.
Baynes J. Perspectives in diabetes. Role of oxidative stress in development of complications in diabetes. Diabetes 1991; 40: 405–412.
Sinclair A, Barnett A, Lunec J. Free radicals and antioxidant systems in health and disease. Br J Hosp Med 1990; 43: 334–344.
Nath N, Chari S, Rath A. SOD in diabetic polymorphonuclear lymphocytes. Diabetes 1984; 33: 586–589.
Kitahara M, Eyre H, Lynch R, Rallison M, Hill H. Metabolic activity of diabetic monocytes. Diabetes 1980; 29: 251–256.
Hiramatsu K, Rosen H, Heinecke J, Wollbauer G, Chait A. Superoxide initiates oxidation of low density lipoprotein by human monocytes. Arteriosclerosis 1987; 7: 55–60.
Sakurai T, Tsuchiya S. Superoxide production from nonenzymatically glycated protein. Fed Eur Biochem Soc 1988; 236: 406–410.
Sakurai T, Sugioka K, Nakano M. 02 generation and lipid peroxidation during the oxidation of glycated polypeptide, glycated polylysine, in the presence of iron-ADP. Biochem Biophys Acta 1990; 1043: 17–33.
Babiy A, Gebicki J, Sullivan DR, Willey K. Increased oxidizability of plasma lipoproteins in diabetic patients can be decreased by probucol therapy and is not due to glycation. Biochem Pharmacol 1992; 43: 995–1000.
Beaudeaux J, Guillausseau P, Peynet J, Flourie F, et al. Enhanced susceptibility of LDL to in vitro oxidation in type 1 and 2 diabetic patients. Clin Chim Acta 1995; 239: 131–141.
Cominacini L, Garbin U, pastorino AM, Pasini A, et al. Increased susceptibility of LDL to in vitro oxidation in patients with IDDM and NIDDM. Diabetes Res 1994; 26: 173–184.
Yoshida H, Ishikawa T, Nakamura H. Vitamin E/Lipid peroxide ratio and susceptibility of LDL to oxidative modification in NIDDM. Arterioscl Thromb Vasc Biol 1997; 17: 1438–1446.
Bellomo G, Maggi E, Poli M, Agosta FG, Bollati P, Finardi G. Autoantibodies against Ox-LDLD in NIDDM. Diabetes 1995; 44: 60–66.
Witztum JL, Mahoney EM, Branks MJ, et al. Nonenzymatic glycation of LDL alters its biologic activity. Diabetes 1982; 31: 283–291.
Nourooz-zadeh J, Sarmadi J, McCarthy S, Betteridge DJ, Wolff SP. Elevated levels of authentic plasma hydroperoxides in NIDDM. Diabetes 1995; 44: 1054–1058.
Oranje WA, Wolffenbuttel BHR. Lipid peroxidation and atherosclerosis in Type 2 diabetes. J Lab Clin Med 1999; 134: 19–32.
Gopaul NK, Anggard EE, Mallet AI, Betteridge DJ, Wolff SP, Nourooz-zadeh. Plasma 8-epi-PGF2alpha are elevated in individuals with NIDDM. FEBS Lett 1995; 368: 225–229.
Davi G, Mezzett A, Vitacolonna E, Constantini F, et al. In vivo formation of 8-epi PGF2-alpha in diabetes mellitus: effect of tight control and vitamin E supplementation. Diabetes 1997; 46: 13.
Bowie A, Owens D, Collins P, Johnson A, Tomkin G. Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient? Atherosclerosis 1993; 102: 63–67.
Mullarkey J, Edelstein D, Brownlee M. Free radical generation by early glycation products: a mechanism for accelerated atherogenesis in diabetes. Biochem Biophys Res Commun 1990; 173: 932–939.
Hunt, JV, Smith, CCT, Wolf, SP. Autoxidative glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose. Diabetes 1990; 39: 1420–1424.
The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. New Engl J Med 1993; 329: 977–986.
UK Prospective Diabetes Study Group. Intensive blood glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998; 352: 837–853.
Ceriello A, Giugliano D, Quatraro A, Donzella C, Diaplo G, Lefevbre PJ. AT reduction of protein glycosylation in diabetics: new prospect for prevention of diabetic complications. Diabetes Care 1991; 14: 68–72.
Ceriello A, Giugliano D, Quatraro A, Dello Russo P, Torella R. A preliminary note on inhibiting effect of alpha-tocopherol (vit. E) on protein glycation. Diab Metab 1988; 14: 40–42.
Jain SK, McVie R, Jaramillo JJ, Palmer M, Smith T. Effect of modest vitamin E supplementation on blood glycated hemoglobin and triglyceride levels and red cell indices in type 1 diabetic patients. J Amer Coll Nutr 1996; 15: 458–461.
Paolisso G, Giugliano D, D’Amore A, et al. Daily vitamin E supplementation improves control but not insulin secretion in elderly type 2 diabetic patients. Diabetes Care 1993; 16: 433–437.
Paolisso G, D’Amore A, Galzerano D, Cacciapuoti F, Varricchio G, Varricchio M, D’Onfario F. Pharmacological doses of vitamin E and insulin action in elderly subjects. Am J Clin Nutr 1994; 59: 1291–1296.
Li DJ, Devaraj S, Fuller CJ, Bucala R, Jialal I. The effect of AT on LDL oxidation and glycation:in vitro and in vivo studies. J Lipid Res 1996; 37: 1978–1986.
Devaraj S, Jialal I. The effect of AT supplementation on monocyte function in Type 2 diabetic subjects with and without macrovascular complications. Circulation 1998; 98: 1601.
Fuller CJ, Chandalia M, Garg A, Grundy SM, Jialal I. RRR-AT acetate supplementation at pharmacological doses decreases LDL oxidation but nor protein glycation in patients with diabetes. Am J Clin Nutr 1996; 63: 753–759.
Giardino I, Edelstein D, Brownlee M. BCL2 expression or antioxidants prevent hyperglycemia-induced formation of AGE in bovine EC. J Clin Invest 1996; 97: 1422–1428.
Reaven PD, Herold DA, Barnett J, Edelman S. Effects of Vitamin Eon susceptibility of LDL and LDL subfractions to oxidation and on protein glycation in NIDDM. Diabetes Care 1995; 18: 807–816.
Kunisaki M, Bursell SE, Clermont AC, Ishii H, Ballas LM, Jirousek MR, et al. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the DAG-PKC pathway. Am J Physiol 1995; 269: E239–246.
Koya D, Haneda M, Kikkawa R, King GL. D-alpha tocopherol prevents glomerular dysfunction in diabetic rats through inhibition of PKC-DAG pathway. Biofactors 1998; 7: 69–76.
Kunisaki M, Bursell SE, Umeda F, Nawata H, King GL. Normalization of DAG-PKC activation by vitamin E in aorta of diabetic rats and cultured rat SMC exposed to elevated glucose levels. Diabetes 1994; 43: 1372–1377.
Bursell S, Clermont AC, Aiello LP, Aiello L, Schlossman DK, Feener EP, Laffel L, King GL. High dose Vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with Type I diabetes. Diabetes Case 1999; 22: 1245–1251.
Jain SK, Krueger KS, McVie R, Jaramillo JJ, Palmer M, Smith T. Relationship of TxB2 with LPO and effect of vitamin Eon these levels in type 1 diabetic patients. Diabetes Care 1998; 21: 1511–1516.
Colette C, Herbute N, Monnier LH, Cartry E. Platelet function in type I diabetes: effects of supplementation with large doses of vitamin E. Am J Clin Nutr 1988; 47: 256–261.
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Devaraj, S., Jialal, I. (2001). Oxidative Stress and Antioxidants in Type 2 Diabetes. In: Bendich, A., Deckelbaum, R.J. (eds) Primary and Secondary Preventive Nutrition. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-039-1_7
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DOI: https://doi.org/10.1007/978-1-59259-039-1_7
Publisher Name: Humana Press, Totowa, NJ
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