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Antioxidant Vitamins and Atherosclerosis

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Primary and Secondary Preventive Nutrition

Part of the book series: Nutrition and Health ((NH))

Abstract

A large body of laboratory evidence suggests that the early stages of atherosclerosis (Athsc) are comprised of a series of oxidative processes (1). Animal studies suggest that oxidative damage may be involved with atherogenic-promoting processes, such as endothelial damage (2), and that antioxidants reduce oxidative damage and Athsc lesions (3,4). As such, a large body of basic science research and animal studies support the antiatherogenic hypothesis of antioxidants. Although information concerning antioxidants and human Athsc is accumulating, the relevance of this hypothesis to Athsc prevention in humans remains unproven.

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Authors
  1. Howard N. Hodis
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  2. Wendy J. Mack
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  3. Alex Sevanian
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Editors and Affiliations

  1. SmithKline Beecham Consumer Healthcare, Parsippany, NJ, USA

    Adrianne Bendich PhD

  2. Institute of Human Nutrition, Columbia University, New York, NY, USA

    Richard J. Deckelbaum MD

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Hodis, H.N., Mack, W.J., Sevanian, A. (2001). Antioxidant Vitamins and Atherosclerosis. In: Bendich, A., Deckelbaum, R.J. (eds) Primary and Secondary Preventive Nutrition. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-039-1_6

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