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Combining Radiation Therapy with Immunotherapy for Treatment of Brain Tumors

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Book cover Brain Tumor Immunotherapy

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Abstract

Radiation therapy (RT) is a common component of the treatment of most intracerebral malignancies. In gliomas, it is used mostly to achieve local/regional control. In most cases, this is still a major challenge. Despite improvements in surgery, RT, and chemotherapy, patients often succumb to persistent local tumor growth or recurrence. Improvements in local control and survival rates may come from new technical advances in the delivery of RT (1–3) Also, as knowledge increases about the signal transduction pathways that determine the intrinsic radio-resistance of cancer, gene therapy approaches are being developed that should increase the probability of local control. However, rational appraisal of the impact of these, and other, newly introduced treatment options suggests that, although the patterns of failure may change, any improvement in survival is likely to be limited to selected patients and to be modest.

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Authors
  1. William H. McBride DSc
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Editors and Affiliations

  1. School of Medicine, University of California at Los Angeles, CA, USA

    Linda M. Liau MD, PhD , Donald P. Becker MD  & Timothy F. Cloughesy MD ,  & 

  2. Department of Pathology and Duke Comprehensive Cancer Center, Duke University Medical Center, Durham, NC, USA

    Darell D. Bigner MD, PhD

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McBride, W.H. (2001). Combining Radiation Therapy with Immunotherapy for Treatment of Brain Tumors. In: Liau, L.M., Becker, D.P., Cloughesy, T.F., Bigner, D.D. (eds) Brain Tumor Immunotherapy. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-035-3_17

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  • DOI: https://doi.org/10.1007/978-1-59259-035-3_17

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-110-3

  • Online ISBN: 978-1-59259-035-3

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