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Melanocortins and Pigmentation

  • Aaron B. Lerner
Chapter
Part of the The Receptors book series (REC)

Abstract

It all began in 1916, the story not only for the melanocortins and pigmentation but also for the entire field of pituitary endocrinology. Two independent papers appeared in Science by two young biologists, Philip E. Smith in California (1) and Bennett M. Allen in Kansas (2). They described a way to ablate the pituitary glands of tadpoles without killing the animals, and they observed that the tadpoles so treated were light in color. Soon after these reports it was found that injections of pituitary extracts into tadpoles and frogs would turn them dark (3). Before this apparently simple achievement, it was thought that the pituitary gland was necessary for life. No investigator had been able to destroy or remove that gland from any animal and keep it alive. Ten years later Smith (4), in another major success, reported his procedure for the ablation of the hypophysis in rats. He opened the door for intense research on the role of the pituitary gland in mammalian systems. It should not be a surprise that a change in color of tadpoles marked the beginning of pituitary endocrinology. It was essential that one be able to see and measure a change with visible light. There were no spectrophotometers or other equipment to monitor the metabolic processes that occurred outside the visible range after the destruction or removal of a gland or the injection of extracts from glands into animals.

Keywords

Pituitary Gland Primary Biliary Cirrhosis Pigment Cell Anterior Lobe Pituitary Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Smith, P. E. (1916) Experimental ablation of the hypophysis in the frog embryo. Science 44, 280.PubMedCrossRefGoogle Scholar
  2. 2.
    Allen, B. M. (1916) The results of extirpation of the anterior lobe of the hypohysis and of the thyroid of rana pipiens larvae. Science 44, 755.CrossRefGoogle Scholar
  3. 3.
    Atwell, W. J. (1919) On the nature of pigmentary changes following hypophysectomy in the frog larvae. Science 39, 48.CrossRefGoogle Scholar
  4. 4.
    Smith, P. E. (1926) Ablation and transplantation of the hypophysis in the rat. Anat. Rec. 32, 221.Google Scholar
  5. 5.
    Lerner, A. B. and McQuire, J. S. (1961) Effect of alpha-and beta-melanocyte stimulating hormones on the skin color of man. Nature 189, 176.PubMedCrossRefGoogle Scholar
  6. 6.
    Lerner, A. B. and Snell, R. S., Chanco-Turner, M. L., and McQuire, J. (1966) Vitiligo and sympathectomy. Arch. Dermatol. 94, 269.PubMedCrossRefGoogle Scholar
  7. 7.
    McQuire, J. S. and Lerner, A. B. (1963) Effects of tricosapeptide “ACTH” and alpha-melanocyte-stimulating hormone on skin color of man. Ann. N. Y. Acad. Sci. 100, 622–630.Google Scholar
  8. 8.
    Lerner, A. B. and McQuire, J. S. (1964) Melanocyte-stimulating hormone and adrenocorticotropic hormone: Their relation to pigmentation. N. Engl. J. Med. 270, 539–546.PubMedCrossRefGoogle Scholar
  9. 9.
    Lerner, A. B., Shizume, K., and Bunding, J. (1954) Endocrine control of pigmentation. J. Clin. Endocrinol. Metab. 14, 1463.PubMedCrossRefGoogle Scholar
  10. 10.
    Dores, R. M., Stevenson, T. C. and Price, M. L. (1993) A view of the N-acetylation of a-melanocyte-stimulating hormone and 13-endorphin from a phylogenetic perspective. Ann. N. Y. Acad. Sci. 680, 161.PubMedCrossRefGoogle Scholar
  11. 11.
    Pears, J. S., Jung, R. T., Bartlett, W., Browning, M. C. K., Kenicer, K., and Thody, A. J. (1992) A case of skin hyperpigmentation due to a-MSH hypersecretion. 126, 286–289.Google Scholar
  12. 12.
    Bergasa, N. V., Vergalla, J., Turner, M. L., Loh, P. Y., and Jones E.A. (1993) a-melanocyte-stimulating hormone in primary biliary cirrhosis. Ann. N. Y. Acad. Sci. 680, 454.Google Scholar
  13. 13.
    Halaban, R., Tyrell, L., Longley, J., Yarden, Y., and Rubn, J. (1993) Pigmentation and proliferation of human melanocytes and the effects of melanocyte-stimulating hormone and ultraviolet B light. Ann. N. Y. Acad. Sci. 680, 290–301.PubMedCrossRefGoogle Scholar
  14. 14.
    Hunt, G. (1995) Melanocyte-stimulating hormone: a regulator of human melanocyte physiology. Pathobiology 63, 12–21.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 2000

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  • Aaron B. Lerner

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