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Overview of Herpesviruses

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Infectious Causes of Cancer

Part of the book series: Infectious Disease ((ID))

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Abstract

Identification of a virus in the family Herpesviridae is based on the morphology of the virus particle. Viewed through an electron microscope, the virions of different members of the Herpesviridae family are indistinguishable and consist of four distinct components: the core, capsid, tegument, and envelope (Fig. 1) (1). The core contains a double-stranded DNA genome arranged in an unusual torus shape that is located inside an icosadeltahedral capsid that is approx 100 nm in size and contains 162 capsomeres (2). Located between the capsid and the viral envelope is an amorphous structure termed the tegument that contains numerous proteins. The tegument structure is generally asymmetrical, although some virus members (such as human herpesvirus 6 [HHV-6] and human herpesvirus 7 [HHV-7]) have been shown to have well-defined tegument structures (3,4). Presumably, the tegument is responsible for connecting the capsid to the envelope and acting as a reservoir for viral proteins that are required during the initial stages of viral infection (5,6). The outermost structure of the herpes virion is the envelope, which is derived from cell nuclear membranes and contains several viral glycoproteins. The size of mature herpesviruses ranges from 120 to 300 nm owing to differences in the size of the individual viral teguments (1).

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Authors
  1. Frank J. Jenkins
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  2. Linda J. Hoffman
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Editors and Affiliations

  1. Viral Epidemiology Branch, National Cancer Institute, 6120 Executive Blvd., Room 8012, MSC 7248, 20852, Rockville, MD, USA

    James J. Goedert MD (Chief) (Chief)

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Jenkins, F.J., Hoffman, L.J. (2000). Overview of Herpesviruses. In: Goedert, J.J. (eds) Infectious Causes of Cancer. Infectious Disease. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-024-7_2

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  • DOI: https://doi.org/10.1007/978-1-59259-024-7_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4684-9621-5

  • Online ISBN: 978-1-59259-024-7

  • eBook Packages: Springer Book Archive

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