Abstract
Advances in noninvasive neuroimaging methods have created unprecedented inroads into the study of central nervous system (CNS) function in vivo. In particular, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) offer numerous opportunities to advance the field of substance abuse research. Clinical cousins to more basic science techniques (e.g., homogenate receptor binding, in vitro autoradiography, and radioimmunoassay), PET and SPECT permit measurements of local neuronal activity, neurochemistry, and pharmacology in the living human brain. The power of such methods, however, comes at the cost of considerable technological complexities that may hinder their appropriate application and interpretation. This chapter summarizes underlying principles, basic limitations, and varied applications of PET and SPECT as they apply to the field of substance abuse research.
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Malison, R.T. (2001). Positron Emission Tomography and Single-Photon Emission Computed Tomography. In: Kaufman, M.J. (eds) Brain Imaging in Substance Abuse. Forensic Science and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-021-6_2
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DOI: https://doi.org/10.1007/978-1-59259-021-6_2
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