Abstract
The ginkgo tree, Ginkgo biloba (L.), is the last remaining member of the Ginkgoaceae family, which once included many species (Tyler, 1993). It has survived unchanged in China for more than 200 million yr, and was brought to Europe in 1730 and to America in 1784. Since then it has become a popular ornamental tree worldwide. Individual trees may live as long as 1000 yr, and grow to a height of about 125 ft (Anonymous, 1998). Ginkgo fruits and seeds have been used in China for their medicinal properties since 2800 bc (Tyler, 1993). Traditional Chinese physicians used ginkgo leaves to treat asthma and chilblains (swelling of the hands and feet from exposure to damp cold) (Anonymous, 1998). The ancient Chinese and Japanese ate roasted ginkgo seeds as a digestive aid and to prevent drunkenness (Anonymous, 1998). Ginkgo use had spread to Europe by the 1960s.
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References
Allain H, Raoul P, Lieury A, LeCoz F, Gandon J. Effect of two doses of Ginkgo biloba extract (EGb 761) on the dual-coding test in elderly subjects. Clin Ther 1993; 15: 549–57.
Amri H, Ogwuegbu SO, Boujrad N, Drieu K, Papadopoulos V. In vivo regulation of peripheral-type benzodiazepine receptor and glucocorticoid synthesis by Ginkgo biloba extract EGb 761 and isolated ginkgolides. Endocrinology 1996; 137: 5707–18.
Anonymous. Ginkgo. In: The review of natural products. St. Louis, Missouri: Facts and Comparisons, 1998.
Anonymous. Ginkgo biloba active ingredients meet proper levels—Consumer Reports. F-D-C Reports. “The Tan Sheet.” March 8, 1999, p. 8.
Arenz A, Klein M, Fiehe K, Groß J, Drewke C, Hemscheidt T, Leistner E. Occurrence of neurotoxic 4’-O-mehtylpyridoxine in Ginkgo biloba leaves, Ginkgo medications, and Japanese ginkgo food. Planta Med 1996; 62: 548–51.
Blumenthal M. Ginkgo biloba. The complete German commission E monographs. Austin, TX, American Botanical Council, 1998.
Chavez ML, Chavez PI. Ginkgo (Part I): History, use, and pharmacologic properties. Hosp Pharm 1998;33:658–72.
Chung KF, McCusker M, Page CP, Dent G, Guinot P, Barnes PJ. Effect of ginkgolide mixture (BN 52063) in antagonizing skin and platelet responses to platelet activating factor in man. Lancet 1987; 1: 248–51.
Duche JC, Barre J Guinot P, Duchier J, Cournot A, Tillement JP. Effect of Ginkgo biloba extract on microsomal enzyme induction. Int J Clin Pharmacol Res 1989; 9: 165–8.
Fourtillan JB, Brisson AM, Girault J, Ingrand I, Decourt JP, Drieu K, et al. Pharmacokinetic properties of bilobalide and ginkgolides A and B in healthy subjects after intravenous and oral administration of Ginkgo biloba extract (EGb 761). Therapie 1995; 50: 137–44.
Gilbert GJ. Ginkgo biloba [letter]. Neurology 1997; 48: 1137.
Hasenohrl RU, Nichau CH, Frisch CH, De Souza Silva MA. Huston JP, Mattem CM
Hacker R. Anxiolytic-like effect of combined extracts of Zingiber officinale andGinkgo biloba in the elevated plus-maze Pharmacol Biochem Behav 1996; 53: 271–5.
Houghton P. Ginkgo. Pharm J 1994; 253: 122–3.
Kim YS, Pyo MK, Park PH, Hahn BS, Wu SJ, Yun-Choi HS. Antiplatelet and antithrombotic effects of a combination of ticlopidine and Ginkgo biloba extract (EGb 761). Thrombos Res 1998; 91: 33–8.
Kleijnen J, Knipschild P. Ginkgo biloba. Lancet 1992; 340: 1136–9.
Jung F, Mroweitz C, Kiesewetter H, Wenzel E. Effect of Ginkgo biloba on fluidity of blood and peripheral microcirculation in volunteers. Arzneim Forsch 1990; 40: 589–93.
Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF, et al. A placebo controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 1997; 278: 1327–32.
Matthews MK. Association of Ginkgo biloba with intracranial hemorrhage [letter]. Neurology 1998; 50: 1933–4.
Nemecz G, Combest WL. Ginkgo biloba. US Pharmacist 1997(Sept):144, 147–8, 151.
Oken BS, Storzbach DM, Kaye JA. The efficacy of Ginkgo biloba on cognitive function in Alzheimer’s disease. Arch Neurol 1998; 55: 1409–15.
Pietta PG, Gardana C, Mauri PL. Identification of Ginkgo flavonol metabolites after oraladministration to humans. J Chromatogr Biomed Sci Appl 1997; 693: 249–55.
Ramassamy C, Clostre F, Christen Y, Costentin J. Prevention by a ginkgo extract (GBE 761) of the dopaminergic neurotoxicity of MPTP. J Pharm Pharmacol 1990; 42: 785–9.
Rosenblatt M, Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract [letter]. N Engl J Med 1997; 336: 1108.
Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas associated with chronic Ginkgo biloba ingestion [letter]. Neurology 1996; 46: 1775–76.
Tyler VE. The honest herbal. 3rd edit., Binghamton, NY: Pharmaceutical Products Press, 1993.
United States Pharmacopoeia (USP). National Formulary. 18th edit., Suppl 9. Rockville, MD: United States Pharmacopeial Convention, 1998.
Vale S. Subarachnoid hemorrhage associated with Ginkgo biloba [letter]. Lancet 1998; 352: 36.
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Mahdavi, F., Cupp, M.J. (2000). Ginkgo biloba. In: Cupp, M.J. (eds) Toxicology and Clinical Pharmacology of Herbal Products. Forensic Science and Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-020-9_4
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DOI: https://doi.org/10.1007/978-1-59259-020-9_4
Publisher Name: Humana Press, Totowa, NJ
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