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Inflammatory Myopathies

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Book cover Principles of Molecular Rheumatology

Part of the book series: Current Molecular Medicine ((CMM,volume 1))

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Abstract

The (idiopathic) inflammatory myopathies are a heterogenous group of diseases, including dermatomyositis (DM), different forms of polymyositis (PM), and inclusionbody myositis (IBM) (reviewed in refs. 1–4). Clinically, DM is distinguished from PM and IBM by characteristic skin manifestations. A microscopic feature highly characteristic of DM is perifascicular atrophy, which is due to degeneration of muscle fibers at the periphery of muscle fascicles secondary to microvascular damage. Quantitative morphological analyses suggest that depletion of capillaries is one of the earliest changes in DM. Immunofluorescence studies revealed the deposition of complement in or around microvascular endothelium in a significant proportion of capillaries (5). These observations support the concept that an antibody- or immune-complex-mediated response against a vascular—endothelial component is a primary pathogenetic mechanism in DM.

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Authors
  1. Norbert Goebels
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  2. Reinhard Hohlfeld
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Editors and Affiliations

  1. Walter Reed Army Institute of Research, Silver Spring, MD, USA

    George C. Tsokos MD

  2. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    George C. Tsokos MD

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Goebels, N., Hohlfeld, R. (2000). Inflammatory Myopathies. In: Tsokos, G.C. (eds) Principles of Molecular Rheumatology. Current Molecular Medicine, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-018-6_22

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  • DOI: https://doi.org/10.1007/978-1-59259-018-6_22

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-182-0

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