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Principles of Molecular Rheumatology pp 325–361Cite as

Rheumatoid Arthritis

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Part of the book series: Current Molecular Medicine ((CMM,volume 1))

Abstract

The normal synovial membrane consists of a synovial lining layer, one to two cell layers deep, that rests on loose areolar connective tissue. The lining layer is comprised of type A macrophage-like synoviocytes and type B fibroblast-like synoviocytes (FLS). There is no discrete basement membrane between the synovial lining and the sublining region. Numerous blood vessels, which are the source of nutrients provided to the normal cartilage and joint space, are present in the sublining region. The junction between the synovial lining and bone and cartilage is a critical region in the pathogenesis of rheumatoid arthritis (RA). Studies have demonstrated the presence of immunocompetent cells overlying and in contact with cartilage and bone in the joints of normal individuals (1). These cells possess markers that indicate the presence of both macrophage-like type A cells and fibroblast-like type B cells, which are not activated in the normal joint.

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Authors
  1. Richard M. Pope
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  2. Harris Perlman
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Editors and Affiliations

  1. Walter Reed Army Institute of Research, Silver Spring, MD, USA

    George C. Tsokos MD

  2. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    George C. Tsokos MD

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Pope, R.M., Perlman, H. (2000). Rheumatoid Arthritis. In: Tsokos, G.C. (eds) Principles of Molecular Rheumatology. Current Molecular Medicine, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-018-6_21

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  • DOI: https://doi.org/10.1007/978-1-59259-018-6_21

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-182-0

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