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Chondrocytes

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Principles of Molecular Rheumatology

Part of the book series: Current Molecular Medicine ((CMM,volume 1))

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Abstract

The basic role of articular cartilage is to serve as a cap on top of skeletal long bones of synovial joints. Articular cartilage is crucial to the normal function of synovial joints because it enables articulating surfaces to transmit high loads while maintaining contact stresses at low levels. In addition, articular cartilage functions to allow articulating surfaces to resist compressive force with low frictional resistance.

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References

  1. Urist, M. K. (1983) The origin of cartilage: investigations in quest of chondrogenic DNA, in Cartilage, Vol. 2, Development, Differentiation and Growth (Hall, B. K., ed.), Academic, New York, pp. 1–85.

    Google Scholar 

  2. Malemud, C. J. and Shuckett, R. (1987) Impact-loading and lower extremity disease, in Clinical Concepts in Regional Musculoskeletal Illness (Hadler, N. M, ed.), Grune & Stratton, Orlando, FL, pp. 109–135.

    Google Scholar 

  3. Malemud, C. J. and Hering, T. M. (1992) Regulation of chondrocytes in osteoarthrosis, in Biological Regulation of the Chondrocytes (Adolphe, M., ed.), CRC, Boca Raton, FL, pp. 295–319.

    Google Scholar 

  4. LuValle, P., Iwamoto, M., Fanning, P., Pacifici, M., and Olsen, B. R. (1993) Multiple negative elements in a gene codes for an extracellular matrix protein, collagen X, restrict expression to the hypertrophic chondrocytes. J. Cell Biol. 121, 1 173–1179.

    Google Scholar 

  5. Warman, M. L., Abbott, M., Apte, S. S., Hefferon, T., McIntosh, I., Cohn, D. H., et al. (1993) A type X collagen mutation causes Schmid metaphyseal chondrodysplasia. Nature Genet. 5, 79–82.

    Article  PubMed  CAS  Google Scholar 

  6. Lefebvre, V. and de Crombrugghe, B. (1997/1998) Toward understanding SOX9 function in chondrocyte differentiation. Matrix Biol. 16, 529–540.

    Article  PubMed  CAS  Google Scholar 

  7. Foster, J. W., Dominguez-Steglich, M. A., Guioli, S., Kwok, C., Weller, P. A., Stevanovic, M., et al. (1994) Campomelic dysplasia and autosomal sex reversal caused by mutations in an SRY-related gene. Nature 372, 525–530.

    Article  PubMed  CAS  Google Scholar 

  8. Aigner, T., Stöß, H., Weseloh, G., Zeiler, G., and von der Mark, K. (1992) Activation of collagen type II expression in osteoarthritic and rheumatoid cartilage. Vichows Arch. B Cell. Pathol. 62, 337–345.

    Article  CAS  Google Scholar 

  9. Caplan, A. I., Elyaderani, M., Mochizuki, Y., Wakitani, S., and Goldberg, V. M. (1997) Principles of cartilage repair and regeneration. Clin. Orthop. Rel. Res. 342, 254–269.

    Article  Google Scholar 

  10. Takahashi, I., Nuckolis, G. H., Takahashi, K., Tanaka, O., Semba, I., Dashner, R., et al. (1998) Compressive force promotes Sox9, type II collagen and aggrecan and inhibits IL-1β expression resulting in chondrogenesis in mouse embryonic limb bud mesenchymal cells. J. Cell Sci. 111, 2067–2076.

    PubMed  CAS  Google Scholar 

  11. Tabin, C. J. and McMahon, A. P. (1997) Recent advances in Hedgehog signalling. Trends Cell Biol. 7, 442–446.

    Article  PubMed  CAS  Google Scholar 

  12. Okano, K., Tsukazaki, T., Ohtsuru, A., Osaki, M., Yonekura, A., Iwasaki, K., et al. (1997) Expression of parathyroid hormone-related peptide in human osteoarthritis. J. Orthop. Res. 15, 175–180.

    Article  PubMed  CAS  Google Scholar 

  13. Tsuji, M., Funahashi, S-i., Takigawa, M., Seiki, M., Fujii, K., and Yoshida, T. (1996) Expression of c-fos inhibits proteoglycans synthesis in transfected chondrocyte. FEBS Lett. 381, 222–226.

    Article  PubMed  CAS  Google Scholar 

  14. Watanabe, H., Saitoh, K., Kameda, T., Murakami, M., Niikura, Y., Okazaki, S., et al. (1997) Chondrocytes as a specific target of ectopic Fos expression in early development. Proc. Natl. Acad. Sci. USA 94, 3994–3999.

    Article  PubMed  CAS  Google Scholar 

  15. Vertel, B. M. (1995) The ins and outs of aggrecan. Trends Cell Biol. 5, 458–464.

    Article  PubMed  CAS  Google Scholar 

  16. Faiyazul Hague, M., King, L. M., Krakow, D., Cantor, R. M., Rusiniak, M. E., Swank, R. T., et al. (1998) Mutations in orthologous genes in human spondylometaphyseal dysplasia and the brachymorphic mouse. Nature Genet. 20, 157–162.

    Article  Google Scholar 

  17. Melching, L. I., Cs-Szabo, G., and Roughley, P. J. (1997) Analysis of proteoglycan messages in human articular cartilage by a competitive PCR technique. Matrix Biol. 16, 1–11.

    Article  PubMed  CAS  Google Scholar 

  18. Nishida, Y., Shinomura, T., Iwata, H., Miura, T., and Kimata, K. (1994) Abnormal occurrence of a large chondroitin-sulfate proteoglycan, PG-M/versican in osteoarthritic cartilage. Osteoarthritis Cart. 2, 43–49.

    Article  CAS  Google Scholar 

  19. Heinegård, D., Lorenzo, P., and Sommarin, Y. (1995) Articular cartilage matrix proteins, in Osteoarthritic Disorders (Kuettner, K. E. and Goldberg, V. M., eds.), American Academy of Orthopaedic Surgeons, Rosemont, IL, pp. 229–237.

    Google Scholar 

  20. Linsenmayer, T. F. (1981) Collagen, in Cell Biology of Extracellular Matrix (Hay, E. D., ed.), Plenum, New York, pp. 1–37.

    Google Scholar 

  21. Sandell, L. J. (1995) Molecular biology of collagens in normal and osteoarthritic cartilage, in Osteoarthritic Disorders (Kuettner, K. E. and Goldberg, V. M., eds.), American Academy of Orthopaedics Surgeons, Rosemont, IL, pp. 131–146.

    Google Scholar 

  22. Aigner, T., Bertling, W., Stöss H., Weseloh, G., and von der Mark, K. (1993) Independent expression of fibril-forming collagens I, II and III in chondrocytes of human osteoarthritic cartilage. J. Clin. Invest. 91, 829–837.

    Article  PubMed  CAS  Google Scholar 

  23. Kuivaniemi, H., Tromp, G., and Prockop, D. J. (1991) Mutations in collagen genes: causes of rare and some common diseases in man. FASEB J. 5, 2052–2060.

    PubMed  CAS  Google Scholar 

  24. Poole, A. R. (1995) Imbalances of anabolism and catabolism of cartilage matrix components in osteoarthritis, in Osteoarthritic Disorders (Kuettner, K. E. and Goldberg, V. M., eds.), American Academy of Orthopaedic Surgeons, Rosemont, IL, pp. 247–260.

    Google Scholar 

  25. Dourado, G. S., Adams, M. E., Matyas, J. R., and Huang, D. (1996) Expression of biglycan, decorin and fibromodulin in the hypertrophic phase of experimental osteoarthritis. Osteoarthritis Cart. 4, 187–196.

    Article  CAS  Google Scholar 

  26. Poole, A. R., Rosenberg, L. C., Reiner, A., Ionescu, M., Bogoch, E., and Roughley, P. J. (1996) Contents and distribution of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilage. J. Orthop. Res. 14, 681–689.

    Article  PubMed  CAS  Google Scholar 

  27. Rizkalla, G., Reiner, A., Bogoch, E., and Poole, A. R. (1992) Studies of the articular cartilage proteoglycan aggrecan in health and disease. Evidence for molecular heterogeneity and extensive molecular change in disease. J. Clin. Invest. 90, 2268–2277.

    Article  PubMed  CAS  Google Scholar 

  28. Woessner, J. F., Jr. (1995) Imbalance of proteinases and their inhibitors in osteoarthritis, in Osteoarthritic Disorders (Kuettner, K. E. and Goldberg, V. M., eds.), American Academy of Orthopaedic Surgeons, Rosemont, IL, pp. 281–290.

    Google Scholar 

  29. Denko, C. W., Boja, B., and Moskowitz, R. W. (1990) Growth promoting peptides in osteoarthritis: insulin, insulin-like growth factor, growth hormone. J. Rheumatol. 17, 1217–1221.

    PubMed  CAS  Google Scholar 

  30. Denko, C. W. and Malemud, C. J. (1999) Metabolic disturbances and synovial joint responses in osteoarthritis. Front. Biosci. 4, D686–D693.

    Google Scholar 

  31. Rizkalla, G., Reiner, A., Bogoch, E., and Poole, A. R. (1992) Studies of the articular cartilage proteoglycan aggrecan in health and disease. Evidence for molecular heterogeneity and extensive molecular change in disease. J. Clin. Invest. 90, 2268–2277.

    Article  PubMed  CAS  Google Scholar 

  32. Reboul, P., Pelletier, J-P., Tardif, G., Cloutier, J.-M., and Martel-Pelletier, J. (1996) The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. J. Clin. Invest. 97, 2011–2019.

    Article  PubMed  CAS  Google Scholar 

  33. Hashimoto, S., Ochs, R. L., Komiya, S., and Lotz, M. (1998) Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis. Arthritis Rheum. 41, 1632–1638.

    Article  PubMed  CAS  Google Scholar 

  34. Blanco, F.J., Ochs, R. L., Schwarz, H., and Lotz, M. (1995) Chondrocyte apoptosis induced by nitric oxide. Am. J. Pathol. 146, 75–85.

    PubMed  CAS  Google Scholar 

  35. Burmester, G. R., Stuhlmuller, B., Keyser, G., and Kinne, R. W. (1997) Mononuclear phagocytes and rheumatoid synovitis: mastermind or workhorse in arthritis. Arthritis Rheum. 40, 5–18.

    Article  PubMed  CAS  Google Scholar 

  36. Goronzy, J. J. and Weyland, C. M. (1995) T cells in rheumatoid arthritis. Rheum. Dis. Clin. North Amer. 21, 655–674.

    CAS  Google Scholar 

  37. Nishioka, K., Hasunuma, T., Kato, T., Sumida, T., and Kobata, T. (1998) Apoptosis in rheumatoid arthritis: a novel pathway in the regulation of synovial tissue. Arthritis Rheum. 41, 1–9.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Tariq M. Haqqi
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  2. Donald D. Anthony
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  3. Charles J. Malemud
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Editor information

Editors and Affiliations

  1. Walter Reed Army Institute of Research, Silver Spring, MD, USA

    George C. Tsokos MD

  2. Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    George C. Tsokos MD

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© 2000 Springer Science+Business Media New York

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Haqqi, T.M., Anthony, D.D., Malemud, C.J. (2000). Chondrocytes. In: Tsokos, G.C. (eds) Principles of Molecular Rheumatology. Current Molecular Medicine, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-018-6_17

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  • DOI: https://doi.org/10.1007/978-1-59259-018-6_17

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-61737-182-0

  • Online ISBN: 978-1-59259-018-6

  • eBook Packages: Springer Book Archive

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