Abstract
Normal synovium is made up of two distinct layers, the synovial lining intima, which is in direct contact with the joint space, and the subsynovium or sublining (1,2). The sublining is relatively acellular, containing blood vessels, fat cells, and fibroblasts.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Müller-Ladner, V., Gay, R. E., and Gay, S. (1997) Structure and function of synoviocytes, in Arthritis and Allied Conditions. A Textbook of Rheumatology (Koopman, W., ed.), Williams and Wilkins, pp. 243–254.
Edwards, J. C. W. (1998) The synovium, in Rheumatology (Klippel, J. H. and Dieppe, P. A., eds.), Mosby, London, pp. 6.1–6.8.
Firestein, G. S. (1998) Rheumatoid synovitis and pannus, in Rheumatology (Klippel, J. H. and Dieppe, P. A., eds.), Mosby, London, pp. 13.1–13.24.
Mojcik, C. F. and Shevach, E. M. (1997) Adhesion molecules: a rheumatologic perspective. [Review]. Arthritis Rheum. 40, 991–1004.
Van Zeben, D., Hazes, J. M., Zwinderman, A. H., et al. (1993) Factors predicting outcome of rheumatoid arthritis results of a follow-up study. J. Rheumatol. 20, 1288–1296.
Mulene, D. G., Wahl, S. M., Tsokos, M., et al. (1984) Immune function in severe, active rheumatoid arthritis: a relationship between peripheral blood mononuclear cell proliferation to soluble antigens and synovial tissue immunohistologic characteristics. J. Clin. Invest. 74, 1173–1185.
Dechanet, J., Merville, P., Durand, I., et al. (1995) The ability of synoviocytes to support terminal differentiation of activated B cells may explain plasma cell accumulation in rheumatoid synovium. J. Clin. Invest. 95, 456–463.
Johnson, B. A., Haines, G. K., Harlow, L. A., and Koch, A. E. (1993) Adhesion molecule expression in human synovial tissue. Arthritis Rheum. 36, 137–146.
Yocum, D. E., Esparza, L., Dubry, S., et al. (1989) Characteristics of tumor necrosis factor production in rheumatoid arthritis. Cell. Immunol. 122, 131–145.
Elliott, M. J., Maini, R. N., Feldmann, M., et al. (1994) Randomized double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor alpha (cAZ) versus placebo in rheumatoid arthritis. Lancet 344, 1105–1110.
Brennan, F. M., Butler, D. M., Maini, R. N., and Feldmann, M. (1995) Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures with an antiTNF-alpha monoclonal antibody: comparison with blockade of IL-1 using the recombinant IL-1 receptor antagonist. Arthritis Rheum. 38, S400.
Fassbender, H. G. (1983) Histomorphologic basis of articular cartilage destruction in rheumatoid arthritis. Cell Related Res. 3, 141–155.
Geiler, T., Kriegsmann, J., Keyszer, G., et al. (1994) A new model for rheumatoid arthritis generated by engraftment of rheumatoid synovial tissue and normal human cartilage into SCID mice. Arthritis Rheum. 37, 1664–1671.
Zvaifler, N. J. and Firestein, G. S. (1994) Pannus and pannocytes. Alternative models of joint destruction in rheumatoid arthritis. Arthritis Rheum. 37, 783–789.
Rendt, K. E., Barry, T. S., Jones, D. M., et al. (1993) Engraftment of human synovium into severe combined immune deficient (SCID) mice: migration of human peripheral blood T-cells to engrafted human synovium and to mouse lymph nodes. J. Immunol. 151, 7324–7336.
Lafyatis, R., Remmers, E. F., Roberts, A. B., et al. (1989) Anchorage independent growth regulation of synoviocytes from arthritis and normal joints stimulation by exogenous plateletderived growth factor and inhibition by transforming growth factor-beta and retinoids. J. Clin. Invest. 83, 1267–1276.
Müller-Ladner, V., Kriegsmann, J., Gay, R. E., et al. (1994) Upregulation of bcl-2 and fas mRNA in synovium of patients with rheumatoid arthritis (RA). Arthritis Rheum. 37, S163.
Frye, C. A., Tuan, R., Yocum, D. E., and Hendrix, M. J. C. (1993) An in vitro model for studying mechanisms underlying cartilage destruction associated with rheumatoid arthritis. Arthritis Rheum. 36, S174.
Trabandt, A., Aicher, W. K., Gay, R. E., et al. (1990) Expression of the collagenolytic and ras-induced cysteine protease cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/1 mice and patients with rheumatoid arthritis. Matrix 10, 349–361.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2000 Springer Science+Business Media New York
About this chapter
Cite this chapter
Yocum, D.E. (2000). Synoviocytes. In: Tsokos, G.C. (eds) Principles of Molecular Rheumatology. Current Molecular Medicine, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-018-6_16
Download citation
DOI: https://doi.org/10.1007/978-1-59259-018-6_16
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61737-182-0
Online ISBN: 978-1-59259-018-6
eBook Packages: Springer Book Archive